IGFBP6

From Wikipedia, the free encyclopedia

Insulin-like growth factor binding protein 6

PDB rendering based on 2jm2.

Available structures: 2jm2

Identifiers

Symbol(s)

IGFBP6; IBP6

External IDs

OMIM: 146735 MGI: 96441 HomoloGene: 1641

Gene ontology
Molecular Function:	• insulin-like growth factor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• regulation of cell growth • signal transduction • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002178 (mRNA)
NP_002169 (protein)

NM_008344 (mRNA)
NP_032370 (protein)

Location

Chr 12: 51.78 - 51.78 Mb

Chr 15: 101.97 - 101.98 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor binding protein 6, also known as IGFBP6, is a human gene.^[1]

[edit] References

^ Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6.

[edit] Further reading

Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461.
Zapf J, Kiefer M, Merryweather J, et al. (1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.". J. Biol. Chem. 265 (25): 14892–8. PMID 1697583.
Kiefer MC, Masiarz FR, Bauer DM, Zapf J (1991). "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum.". J. Biol. Chem. 266 (14): 9043–9. PMID 1709161.
Shimasaki S, Gao L, Shimonaka M, Ling N (1991). "Isolation and molecular cloning of insulin-like growth factor-binding protein-6.". Mol. Endocrinol. 5 (7): 938–48. PMID 1719383.
Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.". Biochem. Biophys. Res. Commun. 176 (1): 213–8. PMID 1850257.
Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein.". Biochem. Biophys. Res. Commun. 176 (1): 219–25. PMID 1850258.
Martin JL, Willetts KE, Baxter RC (1990). "Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts.". J. Biol. Chem. 265 (7): 4124–30. PMID 2154495.
Roghani M, Hossenlopp P, Lepage P, et al. (1989). "Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II.". FEBS Lett. 255 (2): 253–8. PMID 2551732.
Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland.". Mol. Cell. Endocrinol. 97 (1-2): 71–9. PMID 7511544.
Kato M, Ishizaki A, Hellman U, et al. (1995). "A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner.". J. Biol. Chem. 270 (21): 12373–9. PMID 7539002.
Delhanty PJ, Hill DJ, Shimasaki S, Han VK (1993). "Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?". Growth Regul. 3 (1): 8–11. PMID 7683540.
Bach LA, Hsieh S, Sakano K, et al. (1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6.". J. Biol. Chem. 268 (13): 9246–54. PMID 7683646.
Wegmann BR, Schöneberger HJ, Kiefer PE, et al. (1993). "Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours.". Eur. J. Cancer 29A (11): 1578–84. PMID 7692907.
Neumann GM, Marinaro JA, Bach LA (1998). "Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6.". Biochemistry 37 (18): 6572–85. doi:10.1021/bi972894e. PMID 9572875.
Ehrenborg E, Zazzi H, Lagercrantz S, et al. (1999). "Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene.". Mamm. Genome 10 (4): 376–80. PMID 10087296.
Neumann GM, Bach LA (1999). "The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry.". J. Biol. Chem. 274 (21): 14587–94. PMID 10329650.
Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins.". Biochim. Biophys. Acta 1432 (2): 293–301. PMID 10407151.
Yu H, Mistry J, Nicar MJ, et al. (1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation.". J. Clin. Lab. Anal. 13 (4): 166–72. PMID 10414596.
Dailly YP, Zhou Y, Linkhart TA, et al. (2001). "Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element.". Biochim. Biophys. Acta 1518 (1-2): 145–51. PMID 11267670.
Weinzimer SA, Gibson TB, Collett-Solberg PF, et al. (2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein.". J. Clin. Endocrinol. Metab. 86 (4): 1806–13. PMID 11297622.