IGFBP2

From Wikipedia, the free encyclopedia

Insulin-like growth factor binding protein 2, 36kDa

PDB rendering based on 2h7t.

Available structures: 2h7t

Identifiers

Symbol(s)

IGFBP2; IBP2; IGF-BP53

External IDs

OMIM: 146731 MGI: 96437 HomoloGene: 499

Gene ontology
Molecular Function:	• insulin-like growth factor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• regulation of cell growth

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000597 (mRNA)
NP_000588 (protein)

NM_008342 (mRNA)
NP_032368 (protein)

Location

Chr 2: 217.21 - 217.24 Mb

Chr 1: 72.76 - 72.79 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor binding protein 2, 36kDa, also known as IGFBP2, is a human gene.

[edit] Further reading

Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. PMID 9408744.
Wolf E, Lahm H, Wu M, et al. (2000). "Effects of IGFBP-2 overexpression in vitro and in vivo.". Pediatr. Nephrol. 14 (7): 572–8. PMID 10912521.
Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis.". Cytokine Growth Factor Rev. 18 (3-4): 267–78. doi:10.1016/j.cytogfr.2007.04.001. PMID 17485236.
Binkert C, Margot JB, Landwehr J, et al. (1992). "Structure of the human insulin-like growth factor binding protein-2 gene.". Mol. Endocrinol. 6 (5): 826–36. PMID 1376411.
Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development.". Endocrinology 131 (3): 1230–40. PMID 1380437.
Zapf J, Kiefer M, Merryweather J, et al. (1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.". J. Biol. Chem. 265 (25): 14892–8. PMID 1697583.
Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene.". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. PMID 1710112.
Agarwal N, Hsieh CL, Sills D, et al. (1991). "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2).". Exp. Eye Res. 52 (5): 549–61. PMID 1712312.
Roghani M, Lassarre C, Zapf J, et al. (1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins.". J. Clin. Endocrinol. Metab. 73 (3): 658–66. PMID 1714916.
Clemmons DR, Snyder DK, Busby WH (1991). "Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects.". J. Clin. Endocrinol. Metab. 73 (4): 727–33. PMID 1716260.
Roghani M, Segovia B, Whitechurch O, Binoux M (1993). "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species.". Growth Regul. 1 (3): 125–30. PMID 1726837.
Rosenfeld RG, Pham H, Conover CA, et al. (1989). "Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids.". J. Clin. Endocrinol. Metab. 68 (3): 638–46. PMID 2465304.
Binkert C, Landwehr J, Mary JL, et al. (1989). "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2).". EMBO J. 8 (9): 2497–502. PMID 2479552.
Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland.". Mol. Cell. Endocrinol. 97 (1-2): 71–9. PMID 7511544.
Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system.". Biol. Reprod. 48 (3): 467–82. PMID 7680905.
Han VK, Bassett N, Walton J, Challis JR (1996). "The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface.". J. Clin. Endocrinol. Metab. 81 (7): 2680–93. PMID 8675597.
Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography.". Biochim. Biophys. Acta 1313 (1): 79–88. PMID 8781553.
Ho PJ, Baxter RC (1997). "Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia.". Clin. Endocrinol. (Oxf) 46 (3): 333–42. PMID 9156044.
Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins.". Biochim. Biophys. Acta 1432 (2): 293–301. PMID 10407151.