IGF2BP1

From Wikipedia, the free encyclopedia


Insulin-like growth factor 2 mRNA binding protein 1
Identifiers
Symbol(s) IGF2BP1; CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1
External IDs OMIM: 608288 MGI: 1890357 HomoloGene: 4772
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10642 140486
Ensembl ENSG00000159217 ENSMUSG00000013415
Refseq NM_006546 (mRNA)
NP_006537 (protein)		 NM_009951 (mRNA)
NP_034081 (protein)
Location Chr 17: 44.43 - 44.49 Mb Chr 11: 95.78 - 95.82 Mb
Pubmed search [1] [2]

Insulin-like growth factor 2 mRNA binding protein 1, also known as IGF2BP1, is a human gene.[1]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.[1]

[edit] References

  1. ^ a b Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1.

[edit] Further reading

  • Yaniv K, Yisraeli JK (2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis.". Gene 287 (1-2): 49–54. PMID 11992722. 
  • Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.". Biol. Cell 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260. 
  • Prokipcak RD, Herrick DJ, Ross J (1994). "Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA.". J. Biol. Chem. 269 (12): 9261–9. PMID 8132663. 
  • Doyle GA, Betz NA, Leeds PF, et al. (1999). "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins.". Nucleic Acids Res. 26 (22): 5036–44. PMID 9801297. 
  • Nielsen J, Christiansen J, Lykke-Andersen J, et al. (1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.". Mol. Cell. Biol. 19 (2): 1262–70. PMID 9891060. 
  • Runge S, Nielsen FC, Nielsen J, et al. (2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein.". J. Biol. Chem. 275 (38): 29562–9. doi:10.1074/jbc.M001156200. PMID 10875929. 
  • Nielsen FC, Nielsen J, Kristensen MA, et al. (2003). "Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains.". J. Cell. Sci. 115 (Pt 10): 2087–97. PMID 11973350. 
  • Lemm I, Ross J (2002). "Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant.". Mol. Cell. Biol. 22 (12): 3959–69. PMID 12024010. 
  • Ioannidis P, Mahaira L, Papadopoulou A, et al. (2003). "8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas.". Int. J. Cancer 104 (1): 54–9. doi:10.1002/ijc.10794. PMID 12532419. 
  • Nielsen J, Adolph SK, Rajpert-De Meyts E, et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1.". Biochem. J. 376 (Pt 2): 383–91. doi:10.1042/BJ20030943. PMID 12921532. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gu L, Shigemasa K, Ohama K (2004). "Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer.". Int. J. Oncol. 24 (3): 671–8. PMID 14767552. 
  • Hansen TV, Hammer NA, Nielsen J, et al. (2004). "Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice.". Mol. Cell. Biol. 24 (10): 4448–64. PMID 15121863. 
  • Ioannidis P, Kottaridi C, Dimitriadis E, et al. (2004). "Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors.". Cancer Lett. 209 (2): 245–50. doi:10.1016/j.canlet.2003.12.015. PMID 15159028. 
  • Rackham O, Brown CM (2005). "Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs.". EMBO J. 23 (16): 3346–55. doi:10.1038/sj.emboj.7600341. PMID 15282548. 
  • Nielsen J, Kristensen MA, Willemoës M, et al. (2004). "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability.". Nucleic Acids Res. 32 (14): 4368–76. doi:10.1093/nar/gkh754. PMID 15314207. 
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556. 
  • Liao B, Patel M, Hu Y, et al. (2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells.". J. Biol. Chem. 279 (47): 48716–24. doi:10.1074/jbc.M405853200. PMID 15355996. 
 This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.