Talk:Hypericin

From Wikipedia, the free encyclopedia

[edit] Dopamine β-hydroxylase

The statement, "Hypericin may inhibit reuptake of dopamine β-hydroxylase, leading to increased dopamine levels," seems to be misleading and potentialy inacurate. Dopamine β-hydroxylase is an enzyme that converts dopamine into norepinephrine, so one could deduce that increased levels of dopamine β-hydroxylase resulting from its reuptake would not lead to increased levels of dopamine, but rather reduced levels of dopamine and increased levels of norepinephrine. Mike19772007 20:57, 19 July 2007 (UTC)

It is written "Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine"

Dopamine beta-hydroxylase converts dopamine to norepinephrine. If the enzyme is inhibited and no other mechanism compensates for it dopamine levels should increase. Where is the contradiction? -- 16:20, 30 April 2008 (UTC)

[edit] MAOI?

Does hypericin cause monoamine oxidase inhibition? I've seen a few sources which state one should limit tyramine (which MAO cleans up) intake when using St. John's Wort, of which hypericin is a key ingredient. 20.137.18.50 (talk) 15:32, 30 April 2008 (UTC)