Hygromycin-B kinase

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In enzymology, a hygromycin-B kinase (EC 2.7.1.119) is an enzyme that catalyzes the chemical reaction

ATP + hygromycin B ADP + 7"-O-phosphohygromycin

Thus, the two substrates of this enzyme are ATP and hygromycin B, whereas its two products are ADP and [[7-O-phosphohygromycin]].

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:hygromycin-B 7"-O-phosphotransferase. This enzyme is also called hygromycin B phosphotransferase.

[edit] References

• IUBMB entry for 2.7.1.119
• BRENDA references for 2.7.1.119 (Recommended.)
• PubMed references for 2.7.1.119
• PubMed Central references for 2.7.1.119
• Google Scholar references for 2.7.1.119
• Zalacain M, Pardo JM, Jimenez A (1987). "Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus". Eur. J. Biochem. 162: 419–22. doi:10.1111/j.1432-1033.1987.tb10618.x. PMID 3026811. 

[edit] External links

The CAS registry number for this enzyme class is 88361-67-5.

• IUBMB entry for 2.7.1.119

• KEGG entry for 2.7.1.119

• BRENDA entry for 2.7.1.119

• NiceZyme view of 2.7.1.119

• EC2PDB: PDB structures for 2.7.1.119

• PRIAM entry for 2.7.1.119

• PUMA2 entry for 2.7.1.119

• IntEnz: Integrated Enzyme entry for 2.7.1.119

• MetaCyc entry for 2.7.1.119

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008904: hygromycin B kinase

• AMIGO entry for GO code 0008904: hygromycin B kinase