Hydroxynitrilase

From Wikipedia, the free encyclopedia

In enzymology, a hydroxynitrilase (EC 4.1.2.37) is an enzyme that catalyzes the chemical reaction

acetone cyanohydrin cyanide + acetone

Hence, this enzyme has one substrate, acetone cyanohydrin, and two products, cyanide and acetone.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is acetone-cyanohydrin acetone-lyase (cyanide-forming). Other names in common use include alpha-hydroxynitrile lyase, hydroxynitrile lyase, acetone-cyanhydrin lyase [mis-spelt], acetone-cyanohydrin acetone-lyase, oxynitrilase, 2-hydroxyisobutyronitrile acetone-lyase, 2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming), and acetone-cyanohydrin lyase.

[edit] References

• IUBMB entry for 4.1.2.37
• BRENDA references for 4.1.2.37 (Recommended.)
• PubMed references for 4.1.2.37
• PubMed Central references for 4.1.2.37
• Google Scholar references for 4.1.2.37
• Xu LL, Singh BK, Conn EE (1988). "Purification and characterization of acetone cyanohydrin lyase from Linum usitatissimum". Arch. Biochem. Biophys. 263: 256–63. doi:10.1016/0003-9861(88)90634-0. PMID 3377504. 
• Selmar D, Lieberei R, Biehl B, Conn EE (1989). "alpha-Hydroxynitrile lyase in Hevea brasiliensis and its significance for rapid cyanogenesis". Physiol. Plant 75: 97–101. doi:10.1111/j.1399-3054.1989.tb02069.x. 

[edit] External links

The CAS registry number for this enzyme class is 112567-89-2.

• IUBMB entry for 4.1.2.37

• KEGG entry for 4.1.2.37

• BRENDA entry for 4.1.2.37

• NiceZyme view of 4.1.2.37

• EC2PDB: PDB structures for 4.1.2.37

• PRIAM entry for 4.1.2.37

• PUMA2 entry for 4.1.2.37

• IntEnz: Integrated Enzyme entry for 4.1.2.37

• MetaCyc entry for 4.1.2.37

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047606: acetone-cyanhydrin lyase

• AMIGO entry for GO code 0047606: acetone-cyanhydrin lyase