Hydroxymethylglutaryl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a hydroxymethylglutaryl-CoA hydrolase (EC 3.1.2.5) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxy-3-methylglutaryl-CoA + H₂O CoA + 3-hydroxy-3-methylglutarate

Thus, the two substrates of this enzyme are (S)-3-hydroxy-3-methylglutaryl-CoA and H₂O, whereas its two products are CoA and 3-hydroxy-3-methylglutarate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase. Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3-hydroxy-3-methylglutaryl-CoA hydrolase.

[edit] References

• IUBMB entry for 3.1.2.5
• BRENDA references for 3.1.2.5 (Recommended.)
• PubMed references for 3.1.2.5
• PubMed Central references for 3.1.2.5
• Google Scholar references for 3.1.2.5
• DEKKER EE, SCHLESINGER MJ, COON MJ (1958). "beta-Hydroxy-beta-methylglutaryl coenzyme A deacylase". J. Biol. Chem. 233: 434–8. PMID 13563516. 

[edit] External links

The CAS registry number for this enzyme class is 9025-89-2.

• IUBMB entry for 3.1.2.5

• KEGG entry for 3.1.2.5

• BRENDA entry for 3.1.2.5

• NiceZyme view of 3.1.2.5

• EC2PDB: PDB structures for 3.1.2.5

• PRIAM entry for 3.1.2.5

• PUMA2 entry for 3.1.2.5

• IntEnz: Integrated Enzyme entry for 3.1.2.5

• MetaCyc entry for 3.1.2.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047994: hydroxymethylglutaryl-CoA hydrolase

• AMIGO entry for GO code 0047994: hydroxymethylglutaryl-CoA hydrolase