HTATIP2

From Wikipedia, the free encyclopedia

HIV-1 Tat interactive protein 2, 30kDa

PDB rendering based on 2bka.

Available structures: 2bka, 2fmu

Identifiers

Symbol(s)

HTATIP2; CC3; TIP30

External IDs

OMIM: 605628 MGI: 1859271 HomoloGene: 4676

Gene ontology
Molecular Function:	• RNA polymerase II transcription factor activity • transcription coactivator activity • protein binding • oxidoreductase activity
Cellular Component:	• nucleus • nuclear envelope • cytoplasm
Biological Process:	• regulation of transcription from RNA polymerase II promoter • anti-apoptosis • induction of apoptosis • cell cycle • multicellular organismal development • cell differentiation • regulation of apoptosis • regulation of angiogenesis • negative regulation of progression through cell cycle • nuclear import

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006410 (mRNA)
NP_006401 (protein)

NM_016865 (mRNA)
NP_058561 (protein)

Location

Chr 11: 20.34 - 20.36 Mb

Chr 7: 49.63 - 49.64 Mb

Pubmed search

[1]

[2]

HIV-1 Tat interactive protein 2, 30kDa, also known as HTATIP2, is a human gene.^[1] It may be a metastasis suppressor.

[edit] References

^ Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Shtivelman E (1997). "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma.". Oncogene 14 (18): 2167–73. doi:10.1038/sj.onc.1201059. PMID 9174052.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Xiao H, Tao Y, Greenblatt J, Roeder RG (1998). "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2146–51. PMID 9482853.
Baker ME (1999). "TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases.". Curr. Biol. 9 (13): R471. PMID 10395547.
Whitman S, Wang X, Shalaby R, Shtivelman E (2000). "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis.". Mol. Cell. Biol. 20 (2): 583–93. PMID 10611237.
Xiao H, Palhan V, Yang Y, Roeder RG (2000). "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes.". EMBO J. 19 (5): 956–63. doi:10.1093/emboj/19.5.956. PMID 10698937.
Baker ME, Yan L, Pear MR (2000). "Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression.". Cell. Mol. Life Sci. 57 (5): 851–8. PMID 10892349.
NicAmhlaoibh R, Shtivelman E (2001). "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro.". Oncogene 20 (2): 270–5. doi:10.1038/sj.onc.1204075. PMID 11313954.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ito M, Jiang C, Krumm K, et al. (2004). "TIP30 deficiency increases susceptibility to tumorigenesis.". Cancer Res. 63 (24): 8763–7. PMID 14695192.
Jiang C, Ito M, Piening V, et al. (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription.". J. Biol. Chem. 279 (26): 27781–9. doi:10.1074/jbc.M401809200. PMID 15073177.
Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMID 15124103.
King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3.". Mol. Cell. Biol. 24 (16): 7091–101. doi:10.1128/MCB.24.16.7091-7101.2004. PMID 15282309.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sun L, Feng S, Reséndiz JC, et al. (2005). "Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation.". Annals of biomedical engineering 32 (9): 1193–201. PMID 15493507.
Shi M, Zhang X, Wang P, et al. (2005). "TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway.". World J. Gastroenterol. 11 (2): 221–7. PMID 15633220.
El Omari K, Bird LE, Nichols CE, et al. (2005). "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.". J. Biol. Chem. 280 (18): 18229–36. doi:10.1074/jbc.M501113200. PMID 15728189.
Caldwell RL, Lane KB, Shepherd VL (2006). "HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription.". Arch. Biochem. Biophys. 449 (1-2): 27–33. doi:10.1016/j.abb.2006.02.020. PMID 16615932.