HSPB8

From Wikipedia, the free encyclopedia

Heat shock 22kDa protein 8

Identifiers

HSPB8; CMT2L; DHMN2; E2IG1; H11; HMN2; HSP22

External IDs

OMIM: 608014 MGI: 2135756 HomoloGene: 8654

Gene ontology
Molecular Function:	• protein serine/threonine kinase activity • kinase activity • transferase activity • identical protein binding
Cellular Component:	• cellular_component • intracellular
Biological Process:	• protein folding • response to unfolded protein • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014365 (mRNA)
NP_055180 (protein)

NM_030704 (mRNA)
NP_109629 (protein)

Location

Chr 12: 118.1 - 118.12 Mb

Chr 5: 116.67 - 116.68 Mb

Pubmed search

[1]

[2]

Heat shock 22kDa protein 8, also known as HSPB8, is a human gene.^[1]

[edit] References

^ Entrez Gene: HSPB8 Heat shock 22kDa protein 8.

[edit] Further reading

Hu Z, Chen L, Zhang J, et al. (2007). "Structure, function, property, and role in neurologic diseases and other diseases of the sHsp22.". J. Neurosci. Res. 85 (10): 2071–9. doi:10.1002/jnr.21231. PMID 17304582.
Timmerman V, Raeymaekers P, Nelis E, et al. (1992). "Linkage analysis of distal hereditary motor neuropathy type II (distal HMN II) in a single pedigree.". J. Neurol. Sci. 109 (1): 41–8. PMID 1517763.
Berciano J, Combarros O, Figols J, et al. (1986). "Hereditary motor and sensory neuropathy type II. Clinicopathological study of a family.". Brain 109 ( Pt 5): 897–914. PMID 3022865.
Jansen PH, Joosten EM, Jaspar HH, Vingerhoets HM (1986). "A rapidly progressive autosomal dominant scapulohumeral form of spinal muscular atrophy.". Ann. Neurol. 20 (4): 538–40. doi:10.1002/ana.410200417. PMID 3789668.
Meadows JC, Marsden CD (1969). "A distal form of chronic spinal muscular atrophy.". Neurology 19 (1): 53–8. PMID 5813127.
D'Alessandro R, Montagna P, Govoni E, Pazzaglia P (1982). "Benign familial spinal muscular atrophy with hypertrophy of the calves.". Arch. Neurol. 39 (10): 657–60. PMID 7125978.
Groen RJ, Sie OG, van Weerden TW (1993). "Dominant inherited distal spinal muscular atrophy with atrophic and hypertrophic calves.". J. Neurol. Sci. 114 (1): 81–4. PMID 8433103.
Timmerman V, De Jonghe P, Simokovic S, et al. (1997). "Distal hereditary motor neuropathy type II (distal HMN II): mapping of a locus to chromosome 12q24.". Hum. Mol. Genet. 5 (7): 1065–9. PMID 8817349.
Irobi J, Tissir F, De Jonghe P, et al. (2000). "A clone contig of 12q24.3 encompassing the distal hereditary motor neuropathy type II gene.". Genomics 65 (1): 34–43. doi:10.1006/geno.2000.6149. PMID 10777663.
Smith CC, Yu YX, Kulka M, Aurelian L (2000). "A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells.". J. Biol. Chem. 275 (33): 25690–9. doi:10.1074/jbc.M002140200. PMID 10833516.
Charpentier AH, Bednarek AK, Daniel RL, et al. (2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action.". Cancer Res. 60 (21): 5977–83. PMID 11085516.
Aurelian L, Smith CC, Winchurch R, et al. (2001). "A novel gene expressed in human keratinocytes with long-term in vitro growth potential is required for cell growth.". J. Invest. Dermatol. 116 (2): 286–95. doi:10.1046/j.1523-1747.2001.00191.x. PMID 11180006.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Yu YX, Heller A, Liehr T, et al. (2001). "Expression analysis and chromosome location of a novel gene (H11) associated with the growth of human melanoma cells.". Int. J. Oncol. 18 (5): 905–11. PMID 11295034.
Benndorf R, Sun X, Gilmont RR, et al. (2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27).". J. Biol. Chem. 276 (29): 26753–61. doi:10.1074/jbc.M103001200. PMID 11342557.
Kappé G, Verschuure P, Philipsen RL, et al. (2001). "Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9.". Biochim. Biophys. Acta 1520 (1): 1–6. PMID 11470154.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Molloy MP, Andrews PC (2002). "Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated peptides by mass spectrometry.". Anal. Chem. 73 (22): 5387–94. PMID 11816564.
Depre C, Hase M, Gaussin V, et al. (2002). "H11 kinase is a novel mediator of myocardial hypertrophy in vivo.". Circ. Res. 91 (11): 1007–14. PMID 12456486.