HSD17B7

From Wikipedia, the free encyclopedia

Hydroxysteroid (17-beta) dehydrogenase 7

Identifiers

HSD17B7; PRAP; MGC12523; MGC75018

External IDs

OMIM: 606756 MGI: 1330808 HomoloGene: 40728

Gene ontology
Molecular Function:	• estradiol 17-beta-dehydrogenase activity • oxidoreductase activity • 3-keto-steroid reductase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• steroid biosynthetic process • metabolic process

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_016371 (mRNA)
NP_057455 (protein)

NM_010476 (mRNA)
NP_034606 (protein)

Location

n/a

Chr 1: 171.79 - 171.81 Mb

Pubmed search

[1]

[2]

Hydroxysteroid (17-beta) dehydrogenase 7, also known as HSD17B7, is a human gene.^[1]

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7.

[edit] Further reading

Peltoketo H, Nokelainen P, Piao YS, et al. (1999). "Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7.". J. Steroid Biochem. Mol. Biol. 69 (1-6): 431–9. PMID 10419022.
Mendoza-Hernández G, Rendón JL, Díaz-Zagoya JC (1985). "A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta.". Biochem. Biophys. Res. Commun. 126 (1): 477–81. PMID 3855619.
Krazeisen A, Breitling R, Imai K, et al. (1999). "Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1).". FEBS Lett. 460 (2): 373–9. PMID 10544267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Törn S, Nokelainen P, Kurkela R, et al. (2003). "Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7.". Biochem. Biophys. Res. Commun. 305 (1): 37–45. PMID 12732193.
Marijanovic Z, Laubner D, Moller G, et al. (2004). "Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.". Mol. Endocrinol. 17 (9): 1715–25. doi:10.1210/me.2002-0436. PMID 12829805.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ohnesorg T, Adamski J (2005). "Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 259–61. doi:10.1016/j.jsbmb.2005.01.012. PMID 15862973.
Ohnesorg T, Adamski J (2006). "Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region.". Mol. Cell. Endocrinol. 248 (1-2): 164–7. doi:10.1016/j.mce.2005.10.016. PMID 16356630.
Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J (2007). "Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis.". J. Mol. Endocrinol. 37 (1): 185–97. doi:10.1677/jme.1.02043. PMID 16901934.
Smuc T, Pucelj MR, Sinkovec J, et al. (2007). "Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis.". Gynecol. Endocrinol. 23 (2): 105–11. doi:10.1080/09513590601152219. PMID 17454161.
Guggenberger C, Ilgen D, Adamski J (2007). "Functional analysis of cholesterol biosynthesis by RNA interference.". J. Steroid Biochem. Mol. Biol. 104 (3-5): 105–9. doi:10.1016/j.jsbmb.2007.03.001. PMID 17498944.