HSD17B6

From Wikipedia, the free encyclopedia

Hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)

Identifiers

HSD17B6; HSE; RODH

External IDs

OMIM: 606623 MGI: 1351670 HomoloGene: 20811

Gene ontology
Molecular Function:	• electron carrier activity • oxidoreductase activity
Cellular Component:	• intracellular
Biological Process:	• androgen biosynthetic process • androgen catabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003725 (mRNA)
NP_003716 (protein)

XM_988102 (mRNA)
XP_993196 (protein)

Location

Chr 12: 55.44 - 55.47 Mb

Chr 10: 127.39 - 127.4 Mb

Pubmed search

[1]

[2]

Hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse), also known as HSD17B6, is a human gene.^[1]

The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.^[1]

[edit] References

^ ^a ^b Entrez Gene: HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse).

[edit] Further reading

Baker ME (2001). "Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action.". Mol. Cell. Endocrinol. 171 (1-2): 211–5. PMID 11165032.
Biswas MG, Russell DW (1997). "Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate.". J. Biol. Chem. 272 (25): 15959–66. PMID 9188497.
Huang XF, Luu-The V (2000). "Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase.". J. Biol. Chem. 275 (38): 29452–7. doi:10.1074/jbc.M000562200. PMID 10896656.
Kedishvili NY, Belyaeva OV, Gough WH (2001). "Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structure.". Chem. Biol. Interact. 130-132 (1-3): 457–67. PMID 11306067.
Chetyrkin SV, Hu J, Gough WH, et al. (2001). "Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase.". Arch. Biochem. Biophys. 386 (1): 1–10. doi:10.1006/abbi.2000.2203. PMID 11360992.
Huang XF, Luu-The V (2001). "Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha-->beta)-hydroxysteroid epimerase.". Biochim. Biophys. Acta 1520 (2): 124–30. PMID 11513953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jones MR, Italiano L, Wilson SG, et al. (2006). "Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome.". Fertil. Steril. 86 (5): 1438–46. doi:10.1016/j.fertnstert.2006.04.027. PMID 17070195.
Belyaeva OV, Chetyrkin SV, Clark AL, et al. (2007). "Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues.". Endocrinology 148 (5): 2148–56. doi:10.1210/en.2006-1491. PMID 17289849.