HSD17B1

From Wikipedia, the free encyclopedia

Hydroxysteroid (17-beta) dehydrogenase 1

PDB rendering based on 1a27.

Available structures: 1a27, 1bhs, 1dht, 1equ, 1fds, 1fdt, 1fdu, 1fdv, 1fdw, 1i5r, 1iol, 1jtv, 1qyv, 1qyw, 1qyx, 3dhe

Identifiers

Symbol(s)

HSD17B1; EDH17B2; EDHB17; HSD17; MGC138140

External IDs

OMIM: 109684 MGI: 105077 HomoloGene: 37303

Gene ontology
Molecular Function:	• estradiol 17-beta-dehydrogenase activity • oxidoreductase activity
Cellular Component:	• cellular_component • cytoplasm
Biological Process:	• estrogen biosynthetic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000413 (mRNA)
NP_000404 (protein)

NM_010475 (mRNA)
NP_034605 (protein)

Location

Chr 17: 37.95 - 37.96 Mb

Chr 11: 100.89 - 100.9 Mb

Pubmed search

[1]

[2]

Hydroxysteroid (17-beta) dehydrogenase 1, also known as HSD17B1, is a human gene.^[1]

[edit] References

^ Entrez Gene: HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1.

[edit] Further reading

Blomquist CH (1996). "Kinetic analysis of enzymic activities: prediction of multiple forms of 17 beta-hydroxysteroid dehydrogenase.". J. Steroid Biochem. Mol. Biol. 55 (5-6): 515–24. PMID 8547176.
Lin SX, Shi R, Qiu W, et al. (2006). "Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5.". Mol. Cell. Endocrinol. 248 (1-2): 38–46. doi:10.1016/j.mce.2005.11.035. PMID 16480815.
Peltoketo H, Isomaa V, Vihko R (1992). "Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements.". Eur. J. Biochem. 209 (1): 459–66. PMID 1327779.
Winqvist R, Peltoketo H, Isomaa V, et al. (1990). "The gene for 17 beta-hydroxysteroid dehydrogenase maps to human chromosome 17, bands q12-q21, and shows an RFLP with ScaI.". Hum. Genet. 85 (5): 473–6. PMID 1977681.
Luu-The V, Labrie C, Zhao HF, et al. (1990). "Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase.". Ann. N. Y. Acad. Sci. 595: 40–52. PMID 2197970.
Luu-The V, Labrie C, Simard J, et al. (1990). "Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes.". Mol. Endocrinol. 4 (2): 268–75. PMID 2330005.
Baker ME (1989). "Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti.". Mol. Endocrinol. 3 (5): 881–4. PMID 2547159.
Tremblay Y, Ringler GE, Morel Y, et al. (1990). "Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25.". J. Biol. Chem. 264 (34): 20458–62. PMID 2584224.
Luu The V, Labrie C, Zhao HF, et al. (1989). "Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta.". Mol. Endocrinol. 3 (8): 1301–9. PMID 2779584.
Peltoketo H, Isomaa V, Mäentausta O, Vihko R (1988). "Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.". FEBS Lett. 239 (1): 73–7. PMID 2846351.
Nicolas JC, Harris JI (1973). "Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine.". FEBS Lett. 29 (2): 173–6. PMID 4719204.
Burns DJ, Engel LL, Bethune JL (1972). "Amino acid composition and subunit structure. Human placental 17 -estradiol dehydrogenase.". Biochemistry 11 (14): 2699–703. PMID 5045524.
Murdock GL, Chin CC, Offord RE, et al. (1983). "Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione.". J. Biol. Chem. 258 (19): 11460–4. PMID 6578212.
Andersson S, Geissler WM, Patel S, Wu L (1995). "The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases.". J. Steroid Biochem. Mol. Biol. 53 (1-6): 37–9. PMID 7626483.
Tremblay MR, Auger S, Poirier D (1995). "Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD type 1).". Bioorg. Med. Chem. 3 (5): 505–23. PMID 7648200.
Ghosh D, Pletnev VZ, Zhu DW, et al. (1995). "Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.". Structure 3 (5): 503–13. PMID 7663947.
Sawetawan C, Milewich L, Word RA, et al. (1994). "Compartmentalization of type I 17 beta-hydroxysteroid oxidoreductase in the human ovary.". Mol. Cell. Endocrinol. 99 (2): 161–8. PMID 8206323.
Normand T, Narod S, Labrie F, Simard J (1993). "Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21.". Hum. Mol. Genet. 2 (4): 479–83. PMID 8389226.
Zhao Z, Yazdani A, Shen Y, et al. (1996). "Molecular dissection of a cosmid from a gene-rich region in 17q21 and characterization of a candidate gene for alpha-N-acetylglucosaminidase with two cDNA isoforms.". Mamm. Genome 7 (9): 686–90. PMID 8703123.