Host-Cell Reactivation
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The Host-Cell Reactivation Assay or HCR is a technique used to measure the repair capacity of cell of a particular DNA alteration. The host cell is transfected with a damaged plasmid containing a reporter gene, usually luciferase, which has been deactivated due to the damage. The ability of the cell to repair the damage in the plasmid after it is introduced to the cell allows the reporter gene to be reactivated leading it to produce its reporting product.
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