Homotaurine
From Wikipedia, the free encyclopedia
| Homotaurine[1] | |
|---|---|
 |
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| IUPAC name | 3-Aminopropane-1-sulfonic acid |
| Other names | Tramiprosate Alzhemed |
| Identifiers | |
| CAS number | [3687-18-1] |
| PubChem | |
| SMILES | C(CN)CS(=O)(=O)O |
| Properties | |
| Molecular formula | C3H9NO3S |
| Molar mass | 139.17346 |
| Melting point |
293 °C (decomposition) |
| Hazards | |
| R-phrases | R36/37/38 |
| S-phrases | S26 S36 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Homotaurine (also spelled homotaurin) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant.[2]
Homotaurine is also being investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain.[3]
Homotaurine is a zwitterion at neutral pH.
[edit] References
- ^ Homotaurine at Sigma-Aldrich
- ^ Fariello RG, Golden GT, Pisa M (1982). "Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid". Neurology 32 (3): 241–5. PMID 7199633.
- ^ Aisen PS, Gauthier S, Vellas B, et al (2007). "Alzhemed: a potential treatment for Alzheimer's disease". Curr Alzheimer Res 4 (4): 473–8. PMID 17908052.
