Homoserine O-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a homoserine O-acetyltransferase (EC 2.3.1.31) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + L-homoserine CoA + O-acetyl-L-homoserine

Thus, the two substrates of this enzyme are acetyl-CoA and L-homoserine, whereas its two products are CoA and O-acetyl-L-homoserine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:L-homoserine O-acetyltransferase. Other names in common use include homoserine acetyltransferase, homoserine transacetylase, homoserine-O-transacetylase, and L-homoserine O-acetyltransferase. This enzyme participates in methionine metabolism and sulfur metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2B61.

[edit] References

• IUBMB entry for 2.3.1.31
• BRENDA references for 2.3.1.31 (Recommended.)
• PubMed references for 2.3.1.31
• PubMed Central references for 2.3.1.31
• Google Scholar references for 2.3.1.31
• Nagai S, Flavin M (1967). "Acetylhomoserine. An intermediate in the fungal biosynthesis of methionine". J. Biol. Chem. 242: 3884–95. PMID 6037552. 

[edit] External links

The CAS registry number for this enzyme class is 9030-72-2.

• IUBMB entry for 2.3.1.31

• KEGG entry for 2.3.1.31

• BRENDA entry for 2.3.1.31

• NiceZyme view of 2.3.1.31

• EC2PDB: PDB structures for 2.3.1.31

• PRIAM entry for 2.3.1.31

• PUMA2 entry for 2.3.1.31

• IntEnz: Integrated Enzyme entry for 2.3.1.31

• MetaCyc entry for 2.3.1.31

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004414: homoserine O-acetyltransferase

• AMIGO entry for GO code 0004414: homoserine O-acetyltransferase