Homocysteine desulfhydrase

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In enzymology, a homocysteine desulfhydrase (EC 4.4.1.2) is an enzyme that catalyzes the chemical reaction

L-homocysteine + H₂O hydrogen sulfide + NH₃ + 2-oxobutanoate

Thus, the two substrates of this enzyme are L-homocysteine and H₂O, whereas its 3 products are hydrogen sulfide, NH₃, and 2-oxobutanoate.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-homocysteine hydrogen-sulfide-lyase (deaminating 2-oxobutanoate-forming). Other names in common use include homocysteine desulfurase, L-homocysteine hydrogen-sulfide-lyase, and (deaminating). This enzyme participates in nitrogen metabolism and sulfur metabolism. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.4.1.2
• BRENDA references for 4.4.1.2 (Recommended.)
• PubMed references for 4.4.1.2
• PubMed Central references for 4.4.1.2
• Google Scholar references for 4.4.1.2
• KALLIO RE (1951). "Function of pyridoxal phosphate in desulfhydrase systems of Proteus morganii". J. Biol. Chem. 192: 371–7. PMID 14917685. 

[edit] External links

The CAS registry number for this enzyme class is 9024-41-3.

• IUBMB entry for 4.4.1.2

• KEGG entry for 4.4.1.2

• BRENDA entry for 4.4.1.2

• NiceZyme view of 4.4.1.2

• EC2PDB: PDB structures for 4.4.1.2

• PRIAM entry for 4.4.1.2

• PUMA2 entry for 4.4.1.2

• IntEnz: Integrated Enzyme entry for 4.4.1.2

• MetaCyc entry for 4.4.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047982: homocysteine desulfhydrase

• AMIGO entry for GO code 0047982: homocysteine desulfhydrase