Homocysteine S-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a homocysteine S-methyltransferase (EC 2.1.1.10) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + L-homocysteine S-adenosyl-L-homocysteine + L-methionine

Thus, the two substrates of this enzyme are S-adenosyl methionine and L-homocysteine, whereas its two products are S-adenosylhomocysteine and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-homocysteine S-methyltransferase. Other names in common use include S-adenosylmethionine homocysteine transmethylase, S-methylmethionine homocysteine transmethylase, adenosylmethionine transmethylase, methylmethionine:homocysteine methyltransferase, adenosylmethionine:homocysteine methyltransferase, homocysteine methylase, homocysteine methyltransferase, homocysteine transmethylase, L-homocysteine S-methyltransferase, S-adenosyl-L-methionine:L-homocysteine methyltransferase, S-adenosylmethionine-homocysteine transmethylase, and S-adenosylmethionine:homocysteine methyltransferase. This enzyme participates in methionine metabolism.

[edit] References

• IUBMB entry for 2.1.1.10
• BRENDA references for 2.1.1.10 (Recommended.)
• PubMed references for 2.1.1.10
• PubMed Central references for 2.1.1.10
• Google Scholar references for 2.1.1.10
• Balish E, Shapiro SK (1967). "Methionine biosynthesis in Escherichia coli: induction and repression of methylmethionine(or adenosylmethionine):homocysteine methyltransferase". Arch. Biochem. Biophys. 119: 62–8. PMID 4861151. 
• Shapiro SK (1958). "Adenosylmethionine-homocysteine transmethylase". Biochim. Biophys. Acta 29: 405–409. 
• Shapiro SK and Yphantis DA (1959). "Assay of S-methylmethionine and S-adenosylmethionine homocysteine transmethylases". Biochim. Biophys. Acta 36: 241–244. 

[edit] External links

The CAS registry number for this enzyme class is 9012-40-2.

• IUBMB entry for 2.1.1.10

• KEGG entry for 2.1.1.10

• BRENDA entry for 2.1.1.10

• NiceZyme view of 2.1.1.10

• EC2PDB: PDB structures for 2.1.1.10

• PRIAM entry for 2.1.1.10

• PUMA2 entry for 2.1.1.10

• IntEnz: Integrated Enzyme entry for 2.1.1.10

• MetaCyc entry for 2.1.1.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008898: homocysteine S-methyltransferase

• AMIGO entry for GO code 0008898: homocysteine S-methyltransferase