HOMER1

From Wikipedia, the free encyclopedia

Homer homolog 1 (Drosophila)

PDB rendering based on 1ddv.

Available structures: 1ddv, 1ddw, 1i2h

Identifiers

Symbol(s)

HOMER1; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves-1

External IDs

OMIM: 604798 MGI: 1347345 HomoloGene: 3155

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cytoplasm • plasma membrane • integral to plasma membrane
Biological Process:	• metabotropic glutamate receptor, phospholipase C activating pathway • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004272 (mRNA)
NP_004263 (protein)

NM_011982 (mRNA)
NP_036112 (protein)

Location

Chr 5: 78.71 - 78.79 Mb

Chr 13: 94.41 - 94.5 Mb

Pubmed search

[1]

[2]

Homer homolog 1 (Drosophila), also known as HOMER1, is a human gene.^[1]

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.^[1]

[edit] References

^ ^a ^b Entrez Gene: HOMER1 homer homolog 1 (Drosophila).

[edit] Further reading

Xiao B, Tu JC, Worley PF (2000). "Homer: a link between neural activity and glutamate receptor function.". Curr. Opin. Neurobiol. 10 (3): 370–4. PMID 10851183.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Brakeman PR, Lanahan AA, O'Brien R, et al. (1997). "Homer: a protein that selectively binds metabotropic glutamate receptors.". Nature 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Xiao B, Tu JC, Petralia RS, et al. (1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.". Neuron 21 (4): 707–16. PMID 9808458.
Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.". Neuron 21 (4): 717–26. PMID 9808459.
Tu JC, Xiao B, Naisbitt S, et al. (1999). "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.". Neuron 23 (3): 583–92. PMID 10433269.
Roche KW, Tu JC, Petralia RS, et al. (1999). "Homer 1b regulates the trafficking of group I metabotropic glutamate receptors.". J. Biol. Chem. 274 (36): 25953–7. PMID 10464340.
Minakami R, Kato A, Sugiyama H (2000). "Interaction of Vesl-1L/Homer 1c with syntaxin 13.". Biochem. Biophys. Res. Commun. 272 (2): 466–71. doi:10.1006/bbrc.2000.2777. PMID 10833436.
Ango F, Prézeau L, Muller T, et al. (2001). "Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.". Nature 411 (6840): 962–5. doi:10.1038/35082096. PMID 11418862.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
Feng W, Tu J, Yang T, et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex.". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hwang SY, Wei J, Westhoff JH, et al. (2004). "Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling.". Cell Calcium 34 (2): 177–84. PMID 12810060.
Norton N, Williams HJ, Williams NM, et al. (2004). "Mutation screening of the Homer gene family and association analysis in schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 120 (1): 18–21. doi:10.1002/ajmg.b.20032. PMID 12815733.
Westhoff JH, Hwang SY, Duncan RS, et al. (2004). "Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling.". Cell Calcium 34 (3): 261–9. PMID 12887973.
Yuan JP, Kiselyov K, Shin DM, et al. (2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.". Cell 114 (6): 777–89. PMID 14505576.
Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.