HLTF

From Wikipedia, the free encyclopedia

Helicase-like transcription factor

Identifiers

HLTF; HIP116; HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1

External IDs

OMIM: 603257 MGI: 1196437 HomoloGene: 30136

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • RNA polymerase II transcription factor activity • helicase activity • protein binding • ATP binding • zinc ion binding • transcription activator activity • hydrolase activity • ATPase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003071 (mRNA)
NP_003062 (protein)

NM_009210 (mRNA)
NP_033236 (protein)

Location

Chr 3: 150.23 - 150.29 Mb

n/a

Pubmed search

[1]

[2]

Helicase-like transcription factor, also known as HLTF, is a human gene.^[1]

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: HLTF helicase-like transcription factor.

[edit] Further reading

Lin Y, Sheridan PL, Jones KA, Evans GA (1995). "The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is located on human chromosome 3q25.1-q26.1.". Genomics 27 (2): 381-2. doi:10.1006/geno.1995.1064. PMID 7558014.
Sheridan PL, Schorpp M, Voz ML, Jones KA (1995). "Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.". J. Biol. Chem. 270 (9): 4575-87. PMID 7876228.
Descheemaeker K (1993). "On the regulation of the plasminogen activator inhibitor-1 gene expression.". Verh. K. Acad. Geneeskd. Belg. 55 (3): 225-64. PMID 8342330.
Ding H, Descheemaeker K, Marynen P, et al. (1996). "Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene.". DNA Cell Biol. 15 (6): 429-42. PMID 8672239.
Gong X, Kaushal S, Ceccarelli E, et al. (1997). "Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family.". Dev. Biol. 183 (2): 166-82. doi:10.1006/dbio.1996.8486. PMID 9126292.
Ding H, Benotmane AM, Suske G, et al. (1999). "Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.". J. Biol. Chem. 274 (28): 19573-80. PMID 10391891.
Mansharamani M, Hewetson A, Chilton BS (2001). "Cloning and characterization of an atypical Type IV P-type ATPase that binds to the RING motif of RUSH transcription factors.". J. Biol. Chem. 276 (5): 3641-9. doi:10.1074/jbc.M004231200. PMID 11058586.
Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82-96. PMID 11810028.
Moinova HR, Chen WD, Shen L, et al. (2002). "HLTF gene silencing in human colon cancer.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4562-7. doi:10.1073/pnas.062459899. PMID 11904375.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Leung WK, Yu J, Bai AH, et al. (2003). "Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer.". Mol. Carcinog. 37 (2): 91-7. doi:10.1002/mc.10124. PMID 12766908.
Hamai Y, Oue N, Mitani Y, et al. (2004). "DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma.". Cancer Sci. 94 (8): 692-8. PMID 12901794.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853-65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Fukuoka T, Hibi K, Nakao A (2006). "Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma.". Anticancer Res. 26 (5A): 3333-5. PMID 17094449.