HLA-A25

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major histocompatibility complex (human), class I, A25
Alleles A*2501
A*2502
Structure (See HLA-A)
Identifiers
2501 2502
Symbol(s) HLA-A
EBI-HLA A*2501
EBI-HLA A*2502
Shared data
Locus chr.6 6p21.31

HLA-A25 (A25) is an HLA-A serotype. The serotype identifies the more common HLA-A*25 gene products. A25 is a split antigen of the A10 broad antigen serotype group. It is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A26 is more common in Western Europe.


[edit] Serotype

A25 and A10 serotype recognition of HLA A*2501 allele-group gene products[2]
A*25 A25 A10 Sample
allele  %  % size (N)
2501 95 2 1375
2502 80 5

There are 7 alleles for A25, 6 that result in different isoforms.

[edit] A25 frequencies

HLA A*2501 frequencies
freq
ref. Population (%)
[3] Saudi Arabia 5.7
[3] India Jalpaiguri Toto 5.2
[3] Russia Northwest 5.0
[3] Spain Pas Valley 4.3
[3] Czech Republic 4.2
[3] Spain North Cantabrian 4.2
[3] Russia Arkhangelsk Pomors 4.0
[3] Croatia 3.9
[3] Spain North Cabuernigo 3.8
[3] Russia Chuvash 3.7
[3] Romanian 3.5
[3] Italy Bergamo 3.2
[3] Croatia 3.0
[3] Israel Ashkenazi Jews 2.8
[3] Bulgaria 2.7
[3] Spain Basque Arratia Valley 2.7
[3] Sweden Uppsala County 2.6
[3] Ireland Northern 2.1
[3] Turkey 2.1
[3] Wales 2.1
[3] Spain Eastern Andalusia 2.0
[3] Georgia Svaneti Svans 1.9
[3] Italy 1.9
[3] England Manchester 1.9
[3] England Lancaster 1.8
[3] Jews (Israel) 1.7
[3] Macedonia 1.7
[3] England Sheffield 1.6
[3] Portugal South pop2 1.4
[3] Italy South Campania 1.2
[3] Uganda Kampala 1.2
[3] Finland 1.1
[3] Portugal North 1.1
[3] Belgium 1.0
[3] France Corsica 1.0
[3] Mongolia Oold 1.0
[3] Russia Murmansk Saomi 1.0
[3] Tunisia 1.0
[3] France South East 0.8
[3] Morocco Nador Metalsa 0.7
[3] Greece 0.6
[3] Italy North Pavia 0.6
[3] Algeria 0.5
[3] China Qinghai Hui 0.5
[3] Guatemala Mayans 0.4
[3] Russia Nenets 0.4
[3] Cameroon Beti 0.3
[3] Beijing Shijiazhuang 0.1
[3] Taiwan Hakka 0.1

A*2501 distribution is primarily located in western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.

[edit] References

  1. ^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72–80. PMID 8475492. 
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. PMID 12753660. 
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HLA-A serotypes

HLA-A · A1 · A2 · A3 · A9 (A23 · A24) · A10 (A25 · A26 · A34 · A43 · A66) · A11 · A19 (A29 · A30 · A31 · A32 · A33 · A74) · A28 (A68 · A69) · A36 · A80