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| HIV Ribosomal frameshift signal |
 |
| Type: |
Cis-reg; frameshift_element; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
51.9 nucleotides |
| Avg identity: |
90% |
|
The HIV Ribosomal frameshift signal is an RNA element. HIV uses a system called -1 ribosomal frameshifting to produce the required ratio of Gag and Gag-Pol polyproteins. The stem-loop structure of the frameshift signal is thought to impede the ribosome and cause slippage in the 5' direction, this causes the -1 frameshift and translation then continues in the new frame.[1]
[edit] References
- ^ Biswas, P; Jiang X, Pacchia AL, Dougherty JP, Peltz SW (2004). "The human immunodeficiency virus type 1 ribosomal frameshifting site is an invariant sequence determinant and an important target for antiviral therapy". J Virol 78: 2082–2087. doi:10.1128/JVI.78.4.2082-2087.2004. PMID 14747573.
[edit] External links
