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| Histone 3' UTR stem-loop |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
26.0 nucleotides |
| Avg identity: |
78% |
|
The Histone 3' UTR stem-loop is an RNA element involved in nucleocytoplasmic transport of the mRNA, and in stability regulation and translation efficiency in the cytoplasm. The mRNAs of metazoan histone genes lack a poly-A tail. 3' end processing occurs at a site between this highly conserved stem-loop and a purine rich region around 20 nucleotides downstream (the histone downstream element, or HDE). The stem-loop is bound by a 31 kDa stem-loop binding protein (SLBP - also termed the histone hairpin binding protein, or HBP). Together with U7 snRNA binding of the HDE, SLBP binding nucleates the formation of the processing complex.
[edit] References
- [1] Williams, AS; Marzluff WF (1995). "The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein". Nucleic Acids Res 23: 654–662. doi:10.1093/nar/23.4.654. PMID 7899087.
- [2] Dominski, Z; Marzluff WF (1999). "Formation of the 3' end of histone mRNA". Gene 239: 1–14. doi:10.1016/S0378-1119(99)00367-4. PMID 10571029.
[edit] External links
