HIST2H3C

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Histone cluster 2, H3c
PDB rendering based on 1aoi.
Available structures: 1aoi, 1eqz, 1f66, 1hio, 1hq3, 1kx3, 1kx4, 1kx5, 1m18, 1m19, 1m1a, 1p34, 1p3a, 1p3b, 1p3f, 1p3g, 1p3i, 1p3k, 1p3l, 1p3m, 1p3o, 1p3p, 1s32, 1tzy, 1u35, 1zbb, 1zla, 2aro, 2cv5, 2f8n, 2fj7, 2hio, 2hue, 2io5, 2nzd
Identifiers
Symbol(s) HIST2H3C; H3; H3.2; H3/M; H3F2; H3FM; MGC9629; H3/n; H3/o
External IDs OMIM: 142780 MGI: 2448355 HomoloGene: 79492
Orthologs
Human Mouse
Entrez 126961 15077


Refseq XM_001124743 (mRNA)
XP_001124743 (protein)		 XM_886396 (mRNA)
XP_891489 (protein)
Pubmed search [1] [2]

Histone cluster 2, H3c, also known as HIST2H3C, is a human gene.[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.[1]

[edit] References

  1. ^ a b Entrez Gene: HIST2H3C histone cluster 2, H3c.

[edit] Further reading

  • Marashi F, Helms S, Shiels A, et al. (1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences.". Biochem. Cell Biol. 64 (4): 277-89. PMID 3013246. 
  • Green L, Van Antwerpen R, Stein J, et al. (1984). "A major human histone gene cluster on the long arm of chromosome 1.". Science 226 (4676): 838-40. PMID 6494913. 
  • Ohe Y, Iwai K (1982). "Human spleen histone H3. Isolation and amino acid sequence.". J. Biochem. 90 (4): 1205-11. PMID 7309716. 
  • Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M (1996). "Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay.". Biochim. Biophys. Acta 1296 (2): 219-27. PMID 8814229. 
  • Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284-94. PMID 9439656. 
  • El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535-44. PMID 9566873. 
  • Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3.". Mamm. Genome 10 (7): 768-70. PMID 10384058. 
  • Goto H, Tomono Y, Ajiro K, et al. (1999). "Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.". J. Biol. Chem. 274 (36): 25543-9. PMID 10464286. 
  • Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278-95. doi:10.1006/viro.2000.0593. PMID 11080476. 
  • Lachner M, O'Carroll D, Rea S, et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.". Nature 410 (6824): 116-20. doi:10.1038/35065132. PMID 11242053. 
  • Shankaranarayanan P, Chaitidis P, Kühn H, Nigam S (2001). "Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene.". J. Biol. Chem. 276 (46): 42753-60. doi:10.1074/jbc.M102626200. PMID 11509556. 
  • Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312-26. doi:10.1006/viro.2001.1129. PMID 11689053. 
  • Goto H, Yasui Y, Nigg EA, Inagaki M (2002). "Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.". Genes Cells 7 (1): 11-7. PMID 11856369. 
  • Marzluff WF, Gongidi P, Woods KR, et al. (2003). "The human and mouse replication-dependent histone genes.". Genomics 80 (5): 487-98. PMID 12408966. 
  • Ganesan S, Silver DP, Greenberg RA, et al. (2002). "BRCA1 supports XIST RNA concentration on the inactive X chromosome.". Cell 111 (3): 393-405. PMID 12419249. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Goo YH, Sohn YC, Kim DH, et al. (2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.". Mol. Cell. Biol. 23 (1): 140-9. PMID 12482968. 
  • Preuss U, Landsberg G, Scheidtmann KH (2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.". Nucleic Acids Res. 31 (3): 878-85. PMID 12560483. 
  • Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.". EMBO J. 22 (6): 1336-46. doi:10.1093/emboj/cdg120. PMID 12628926. 
  • Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.". EMBO J. 22 (24): 6550-61. doi:10.1093/emboj/cdg631. PMID 14657027. 
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