HIST1H2BG

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Histone cluster 1, H2bg
PDB rendering based on 1aoi.
Available structures: 1aoi, 1eqz, 1f66, 1hio, 1hq3, 1kx3, 1kx4, 1kx5, 1m18, 1m19, 1m1a, 1p34, 1p3a, 1p3b, 1p3f, 1p3g, 1p3i, 1p3k, 1p3l, 1p3m, 1p3o, 1p3p, 1s32, 1tzy, 1u35, 1zbb, 1zla, 2aro, 2cv5, 2f8n, 2fj7, 2hio, 2nzd
Identifiers
Symbol(s) HIST1H2BG; H2B.1A; H2B/a; H2BFA; HIST1H2BF; HIST1H2BI; dJ221C16.8
External IDs OMIM: 602798 MGI: 2448404 HomoloGene: 86899
Orthologs
Human Mouse
Entrez 8339 319186
Ensembl n/a ENSMUSG00000058189
Uniprot n/a P10854
Refseq NM_003518 (mRNA)
NP_003509 (protein)		 NM_178200 (mRNA)
NP_835507 (protein)
Location n/a Chr 13: 21.73 - 21.73 Mb
Pubmed search [1] [2]

Histone cluster 1, H2bg, also known as HIST1H2BG, is a human gene.[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[1]

[edit] References

  1. ^ a b Entrez Gene: HIST1H2BG histone cluster 1, H2bg.

[edit] Further reading

  • Ohe Y, Hayashi H, Iwai K (1979). "Human spleen histone H2B. Isolation and amino acid sequence.". J. Biochem. 85 (2): 615-24. PMID 422550. 
  • Albig W, Kardalinou E, Drabent B, et al. (1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes.". Genomics 10 (4): 940-8. PMID 1916825. 
  • Frohm M, Gunne H, Bergman AC, et al. (1996). "Biochemical and antibacterial analysis of human wound and blister fluid.". Eur. J. Biochem. 237 (1): 86-92. PMID 8620898. 
  • Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M (1996). "Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay.". Biochim. Biophys. Acta 1296 (2): 219-27. PMID 8814229. 
  • Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster.". Genomics 40 (2): 314-22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  • Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284-94. PMID 9439656. 
  • El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535-44. PMID 9566873. 
  • Piredda L, Farrace MG, Lo Bello M, et al. (1999). "Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis.". FASEB J. 13 (2): 355-64. PMID 9973324. 
  • Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278-95. doi:10.1006/viro.2000.0593. PMID 11080476. 
  • Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312-26. doi:10.1006/viro.2001.1129. PMID 11689053. 
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298. 
  • Kim HS, Cho JH, Park HW, et al. (2002). "Endotoxin-neutralizing antimicrobial proteins of the human placenta.". J. Immunol. 168 (5): 2356-64. PMID 11859126. 
  • Marzluff WF, Gongidi P, Woods KR, et al. (2003). "The human and mouse replication-dependent histone genes.". Genomics 80 (5): 487-98. PMID 12408966. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cheung WL, Ajiro K, Samejima K, et al. (2003). "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.". Cell 113 (4): 507-17. PMID 12757711. 
  • Tollin M, Bergman P, Svenberg T, et al. (2004). "Antimicrobial peptides in the first line defence of human colon mucosa.". Peptides 24 (4): 523-30. PMID 12860195. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Coleman MA, Miller KA, Beernink PT, et al. (2004). "Identification of chromatin-related protein interactions using protein microarrays.". Proteomics 3 (11): 2101-7. doi:10.1002/pmic.200300593. PMID 14595808. 
  • Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.". EMBO J. 22 (24): 6550-61. doi:10.1093/emboj/cdg631. PMID 14657027. 
  • Howell SJ, Wilk D, Yadav SP, Bevins CL (2004). "Antimicrobial polypeptides of the human colonic epithelium.". Peptides 24 (11): 1763-70. doi:10.1016/j.peptides.2003.07.028. PMID 15019208. 
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