HINT1

From Wikipedia, the free encyclopedia

Histidine triad nucleotide binding protein 1

PDB rendering based on 1av5.

Available structures: 1av5, 1kpa, 1kpb, 1kpc, 1kpe, 1kpf, 1rzy, 3rhn, 4rhn, 5rhn, 6rhn

Identifiers

Symbol(s)

HINT1; HINT; PKCI-1; PRKCNH1

External IDs

OMIM: 601314 MGI: 1321133 HomoloGene: 3904

Gene ontology
Molecular Function:	• protein kinase C binding • zinc ion binding • hydrolase activity
Cellular Component:	• nucleus • cytoskeleton
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005340 (mRNA)
NP_005331 (protein)

NM_008248 (mRNA)
NP_032274 (protein)

Location

Chr 5: 130.52 - 130.53 Mb

Chr 11: 54.71 - 54.71 Mb

Pubmed search

[1]

[2]

Histidine triad nucleotide binding protein 1, also known as HINT1, is a human gene.^[1]

[edit] References

^ Entrez Gene: HINT1 histidine triad nucleotide binding protein 1.

[edit] Further reading

Brzoska PM, Chen H, Zhu Y, et al. (1995). "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7824-8. PMID 7644499.
Lima CD, Klein MG, Weinstein IB, Hendrickson WA (1996). "Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins.". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5357-62. PMID 8643579.
Brzoska PM, Chen H, Levin NA, et al. (1997). "Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1).". Genomics 36 (1): 151-6. doi:10.1006/geno.1996.0435. PMID 8812426.
Lima CD, Klein MG, Hendrickson WA (1997). "Structure-based analysis of catalysis and substrate definition in the HIT protein family.". Science 278 (5336): 286-90. PMID 9323207.
Klein MG, Yao Y, Slosberg ED, et al. (1998). "Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family.". Exp. Cell Res. 244 (1): 26-32. doi:10.1006/excr.1998.4153. PMID 9770345.
Weitzdoerfer R, Stolzlechner D, Dierssen M, et al. (2002). "Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.". J. Neural Transm. Suppl. (61): 347-59. PMID 11771757.
Bieganowski P, Garrison PN, Hodawadekar SC, et al. (2002). "Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3.". J. Biol. Chem. 277 (13): 10852-60. doi:10.1074/jbc.M111480200. PMID 11805111.
Brenner C (2002). "Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.". Biochemistry 41 (29): 9003-14. PMID 12119013.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes.". J. Neurovirol. 9 (3): 358-71. PMID 12775419.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Weiske J, Huber O (2006). "The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.". J. Biol. Chem. 281 (37): 27356-66. doi:10.1074/jbc.M513452200. PMID 16835243.
Ajit SK, Ramineni S, Edris W, et al. (2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.". Cell. Signal. 19 (4): 723-30. doi:10.1016/j.cellsig.2006.09.008. PMID 17126529.