HGS (gene)

From Wikipedia, the free encyclopedia

Hepatocyte growth factor-regulated tyrosine kinase substrate

Identifiers

HGS; HRS; ZFYVE8

External IDs

OMIM: 604375 MGI: 104681 HomoloGene: 37954

Gene ontology
Molecular Function:	• molecular_function • zinc ion binding • metal ion binding
Cellular Component:	• cytoplasm • endosome • membrane
Biological Process:	• intracellular protein transport • signal transduction • negative regulation of cell proliferation • endosome transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004712 (mRNA)
NP_004703 (protein)

NM_008244 (mRNA)
NP_032270 (protein)

Location

Chr 17: 77.26 - 77.28 Mb

Chr 11: 120.28 - 120.3 Mb

Pubmed search

[1]

[2]

Hepatocyte growth factor-regulated tyrosine kinase substrate, also known as HGS, is a human gene.^[1]

[edit] References

^ Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate.

[edit] Further reading

Comoglio PM (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells.". EXS 65: 131-65. PMID 8380735.
Komada M, Masaki R, Yamamoto A, Kitamura N (1997). "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes.". J. Biol. Chem. 272 (33): 20538-44. PMID 9252367.
Asao H, Sasaki Y, Arita T, et al. (1998). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.". J. Biol. Chem. 272 (52): 32785-91. PMID 9407053.
Lu L, Komada M, Kitamura N (1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17.". Gene 213 (1-2): 125-32. PMID 9630564.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin.". J. Biol. Chem. 274 (42): 30080-6. PMID 10514494.
Bean AJ, Davanger S, Chou MF, et al. (2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15.". J. Biol. Chem. 275 (20): 15271-8. PMID 10809762.
Kwong J, Roundabush FL, Hutton Moore P, et al. (2000). "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis.". J. Cell. Sci. 113 ( Pt 12): 2273-84. PMID 10825299.
Scoles DR, Huynh DP, Chen MS, et al. (2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate.". Hum. Mol. Genet. 9 (11): 1567-74. PMID 10861283.
Gillooly DJ, Morrow IC, Lindsay M, et al. (2000). "Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells.". EMBO J. 19 (17): 4577-88. doi:10.1093/emboj/19.17.4577. PMID 10970851.
Miura S, Takeshita T, Asao H, et al. (2001). "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.". Mol. Cell. Biol. 20 (24): 9346-55. PMID 11094085.
Chin LS, Raynor MC, Wei X, et al. (2001). "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor.". J. Biol. Chem. 276 (10): 7069-78. doi:10.1074/jbc.M004129200. PMID 11110793.
Gutmann DH, Haipek CA, Burke SP, et al. (2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility.". Hum. Mol. Genet. 10 (8): 825-34. PMID 11285248.
Sasaki Y, Sugamura K (2001). "Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1.". J. Biol. Chem. 276 (32): 29943-52. doi:10.1074/jbc.M104230200. PMID 11397816.
Raiborg C, Bremnes B, Mehlum A, et al. (2001). "FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes.". J. Cell. Sci. 114 (Pt 12): 2255-63. PMID 11493665.
Raiborg C, Bache KG, Mehlum A, et al. (2001). "Hrs recruits clathrin to early endosomes.". EMBO J. 20 (17): 5008-21. doi:10.1093/emboj/20.17.5008. PMID 11532964.
Steen H, Kuster B, Fernandez M, et al. (2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.". J. Biol. Chem. 277 (2): 1031-9. doi:10.1074/jbc.M109992200. PMID 11687594.
Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates.". J. Cell Biol. 157 (1): 91-101. doi:10.1083/jcb.200112080. PMID 11916981.
Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.". Mol. Med. 8 (1): 56-64. PMID 11984006.
Li Y, Chin LS, Levey AI, Li L (2002). "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking.". J. Biol. Chem. 277 (31): 28212-21. doi:10.1074/jbc.M111612200. PMID 12021262.