HgcE RNA

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HgcE RNA

Type:	Gene;
2° structure:	Predicted; PFOLD
Seed alignment:	Bateman A
Avg length:	130.0 nucleotides
Avg identity:	81%

The HgcE RNA (also known as Pf3 RNA) gene is a non-coding RNA that was identified computationally and experimentally verified in AT-rich hyperthermophiles.^[1] The genes in the screen were named hgcA through hgcG ("high GC"). The HgcE has been renamed as Pf3 and identified as an H/ACA snoRNA that is suggested to target 23S rRNA for pseudouridylation.^[2] This RNA contains two K-turn motifs.^[2]

[edit] References

^ Klein, RJ; Misulovin Z, Eddy SR (2002). "Noncoding RNA genes identified in AT-rich hyperthermophiles". Proc Natl Acad Sci U S A 99: 7542–7547. doi:10.1073/pnas.112063799. PMID 12032319.
^ ^a ^b Rozhdestvensky TS, Tang TH, Tchirkova IV, Brosius J, Bachellerie JP, Hüttenhofer A (February 2003). "Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea". Nucleic Acids Res. 31 (3): 869–77. PMID 12560482. PMC:149196.