HEXIM1

From Wikipedia, the free encyclopedia

Hexamethylene bis-acetamide inducible 1

Identifiers

HEXIM1; EDG1; HIS1; CLP1; FLJ13562; MAQ1

External IDs

OMIM: 607328 MGI: 2385923 HomoloGene: 31382

Gene ontology
Molecular Function:	• cyclin-dependent protein kinase inhibitor activity • protein binding • transcription repressor activity • snRNA binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • negative regulation of cyclin-dependent protein kinase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006460 (mRNA)
NP_006451 (protein)

NM_138753 (mRNA)
NP_620092 (protein)

Location

Chr 17: 40.58 - 40.59 Mb

Chr 11: 102.93 - 102.94 Mb

Pubmed search

[1]

[2]

Hexamethylene bis-acetamide inducible 1, also known as HEXIM1, is a human gene.^[1]

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.^[1]

[edit] References

^ ^a ^b Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1.

[edit] Further reading

Wolff A (1976). "[Problem of occupational disability hazards]". Lebensversicherungs Medizin 28 (3): 76–7. PMID 9544.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Huang F, Wagner M, Siddiqui MA (2002). "Structure, expression, and functional characterization of the mouse CLP-1 gene.". Gene 292 (1-2): 245–59. PMID 12119119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ouchida R, Kusuhara M, Shimizu N, et al. (2003). "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells.". Genes Cells 8 (2): 95–107. PMID 12581153.
Michels AA, Nguyen VT, Fraldi A, et al. (2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.". Mol. Cell. Biol. 23 (14): 4859–69. PMID 12832472.
Yik JH, Chen R, Nishimura R, et al. (2003). "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.". Mol. Cell 12 (4): 971–82. PMID 14580347.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Paushkin SV, Patel M, Furia BS, et al. (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.". Cell 117 (3): 311–21. PMID 15109492.
Yik JH, Chen R, Pezda AC, et al. (2004). "A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.". Mol. Cell. Biol. 24 (12): 5094–105. doi:10.1128/MCB.24.12.5094-5105.2004. PMID 15169877.
Michels AA, Fraldi A, Li Q, et al. (2005). "Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.". EMBO J. 23 (13): 2608–19. doi:10.1038/sj.emboj.7600275. PMID 15201869.
Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.". J. Biol. Chem. 280 (16): 16368–76. doi:10.1074/jbc.M500912200. PMID 15713661.
Byers SA, Price JP, Cooper JJ, et al. (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.". J. Biol. Chem. 280 (16): 16360–7. doi:10.1074/jbc.M500424200. PMID 15713662.
Schulte A, Czudnochowski N, Barboric M, et al. (2005). "Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.". J. Biol. Chem. 280 (26): 24968–77. doi:10.1074/jbc.M501431200. PMID 15855166.
Wittmann BM, Fujinaga K, Deng H, et al. (2005). "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1.". Oncogene 24 (36): 5576–88. doi:10.1038/sj.onc.1208728. PMID 15940264.
Shimizu N, Ouchida R, Yoshikawa N, et al. (2005). "HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8555–60. doi:10.1073/pnas.0409863102. PMID 15941832.
Li Q, Price JP, Byers SA, et al. (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.". J. Biol. Chem. 280 (31): 28819–26. doi:10.1074/jbc.M502712200. PMID 15965233.
Fraldi A, Varrone F, Napolitano G, et al. (2006). "Inhibition of Tat activity by the HEXIM1 protein.". Retrovirology 2: 42. doi:10.1186/1742-4690-2-42. PMID 15992410.
Dulac C, Michels AA, Fraldi A, et al. (2005). "Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer.". J. Biol. Chem. 280 (34): 30619–29. doi:10.1074/jbc.M502471200. PMID 15994294.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.