Hepoxilin-epoxide hydrolase

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In enzymology, a hepoxilin-epoxide hydrolase (EC 3.3.2.7) is an enzyme that catalyzes the chemical reaction

(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14- trienoate + H₂O $\rightleftharpoons$ (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate

The 3 substrates of this enzyme are (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-, trienoate, and H₂O, whereas its product is (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoat e hydrolase. Other names in common use include hepoxilin epoxide hydrolase, hepoxylin hydrolase, and hepoxilin A3 hydrolase. This enzyme participates in arachidonic acid metabolism.

[edit] References

IUBMB entry for 3.3.2.7
BRENDA references for 3.3.2.7 (Recommended.)
PubMed references for 3.3.2.7
PubMed Central references for 3.3.2.7
Google Scholar references for 3.3.2.7
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Pace-Asciak CR, Lee WS (1989). "Purification of hepoxilin epoxide hydrolase from rat liver". J. Biol. Chem. 264: 9310–3. PMID 2722835.
Fretland AJ, Omiecinski CJ (2000). "Epoxide hydrolases: biochemistry and molecular biology". Chem. Biol. Interact. 129: 41–59. doi:10.1016/S0009-2797(00)00197-6. PMID 11154734.
Newman JW, Morisseau C, Hammock BD (2005). "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid. Res. 44: 1–51. doi:10.1016/j.plipres.2004.10.001. PMID 15748653.