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| Hepatitis C alternative reading frame stem-loop |
 |
| Type: |
Cis-reg; |
| 2° structure: |
INFERNAL |
| Seed alignment: |
Predicted; RNAalifold; |
| Avg length: |
152.0 nucleotides |
| Avg identity: |
92% |
|
Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome.
The core protein-coding region of the Hepatitis C virus (HCV) genome contains a +1 alternative reading frame (ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures [1]. The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication [1]. The two predicted stem loops shown here (SLV and SLVI) are proposed to be important for HCV translation and repression [1]. These stem loops are located downstream of the Internal ribosome entry site (IRES) but their functional role is unknown [1].
[edit] References
- [1] McMullan LK, Grakoui A, Evans MJ, Mihalik K, Puig M, Branch AD,Feinstone SM, Rice CM; (2007). "Evidence for a functional RNA element in the hepatitis C virus coregene.". Proc Natl Acad Sci U S A 104: 2879–2884. doi:10.1073/pnas.0611267104. PMID 17299041.
[edit] External links
