Heparin-sulfate lyase

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In enzymology, a heparin-sulfate lyase (EC 4.2.2.8) is an enzyme that catalyzes the chemical reaction

Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is heparin-sulfate lyase. Other names in common use include heparin-sulfate eliminase, heparitin-sulfate lyase, heparitinase I, and heparitinase II.

[edit] References

• IUBMB entry for 4.2.2.8
• BRENDA references for 4.2.2.8 (Recommended.)
• PubMed references for 4.2.2.8
• PubMed Central references for 4.2.2.8
• Google Scholar references for 4.2.2.8
• Hovingh P, Linker A (1970). "The enzymatic degradation of heparin and heparitin sulfate. 3 Purification of a heparitinase and a heparinase from flavobacteria". J. Biol. Chem. 245: 6170–5. PMID 5484472. 

[edit] External links

The CAS registry number for this enzyme class is 37290-86-1.

• IUBMB entry for 4.2.2.8

• KEGG entry for 4.2.2.8

• BRENDA entry for 4.2.2.8

• NiceZyme view of 4.2.2.8

• EC2PDB: PDB structures for 4.2.2.8

• PRIAM entry for 4.2.2.8

• PUMA2 entry for 4.2.2.8

• IntEnz: Integrated Enzyme entry for 4.2.2.8

• MetaCyc entry for 4.2.2.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0015021: heparin-sulfate lyase

• AMIGO entry for GO code 0015021: heparin-sulfate lyase