Heparin-binding EGF-like growth factor

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Heparin-binding EGF-like growth factor
PDB rendering based on 1xdt.
Available structures: 1xdt
Identifiers
Symbol(s) HBEGF; DTR; DTS; DTSF; HEGFL
External IDs OMIM: 126150 MGI: 96070 HomoloGene: 1466
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1839 15200
Ensembl ENSG00000113070 ENSMUSG00000024486
Uniprot Q99075 Q5FW64
Refseq NM_001945 (mRNA)
NP_001936 (protein)		 NM_010415 (mRNA)
NP_034545 (protein)
Location Chr 5: 139.69 - 139.71 Mb Chr 18: 36.63 - 36.64 Mb
Pubmed search [1] [2]

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.[1]

[edit] References

  1. ^ Nanba D. and Higashiyama S. (2004). "Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor". Cytokine Growth Factor Rev. 15 (1): 13–19. doi:10.1016/j.cytogfr.2003.10.002. PMID 14746810. 

[edit] Further reading

  • Higashiyama S, Lau K, Besner GE, et al. (1992). "Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.". J. Biol. Chem. 267 (9): 6205–12. PMID 1556128. 
  • Yoshizumi M, Kourembanas S, Temizer DH, et al. (1992). "Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells.". J. Biol. Chem. 267 (14): 9467–9. PMID 1577791. 
  • Higashiyama S, Abraham JA, Miller J, et al. (1991). "A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.". Science 251 (4996): 936–9. PMID 1840698. 
  • Iwamoto R, Senoh H, Okada Y, et al. (1991). "An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor.". J. Biol. Chem. 266 (30): 20463–9. PMID 1939101. 
  • Hayes H, Kaneda Y, Uchida T, Okada Y (1988). "Regional assignment of the gene for diphtheria toxin sensitivity using subchromosomal fragments in microcell hybrids.". Chromosoma 96 (1): 26–32. PMID 3436221. 
  • Bennett KL, Jackson DG, Simon JC, et al. (1995). "CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.". J. Cell Biol. 128 (4): 687–98. PMID 7532176. 
  • Pathak BG, Gilbert DJ, Harrison CA, et al. (1995). "Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl).". Genomics 28 (1): 116–8. doi:10.1006/geno.1995.1116. PMID 7590736. 
  • Mitamura T, Higashiyama S, Taniguchi N, et al. (1995). "Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.". J. Biol. Chem. 270 (3): 1015–9. PMID 7836353. 
  • Hashimoto K, Higashiyama S, Asada H, et al. (1994). "Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes.". J. Biol. Chem. 269 (31): 20060–6. PMID 8051092. 
  • Kobrin MS, Funatomi H, Friess H, et al. (1994). "Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer.". Biochem. Biophys. Res. Commun. 202 (3): 1705–9. doi:10.1006/bbrc.1994.2131. PMID 8060360. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Thompson SA, Higashiyama S, Wood K, et al. (1994). "Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin.". J. Biol. Chem. 269 (4): 2541–9. PMID 8300582. 
  • Fen Z, Dhadly MS, Yoshizumi M, et al. (1993). "Structural organization and chromosomal assignment of the gene encoding the human heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor.". Biochemistry 32 (31): 7932–8. PMID 8347598. 
  • Elenius K, Paul S, Allison G, et al. (1997). "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.". EMBO J. 16 (6): 1268–78. doi:10.1093/emboj/16.6.1268. PMID 9135143. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Louie GV, Yang W, Bowman ME, Choe S (1998). "Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor.". Mol. Cell 1 (1): 67–78. PMID 9659904. 
  • Borer JG, Park JM, Atala A, et al. (1999). "Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction.". Lab. Invest. 79 (11): 1335–45. PMID 10576204. 
  • Nakamura K, Mitamura T, Takahashi T, et al. (2000). "Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity.". J. Biol. Chem. 275 (24): 18284–90. doi:10.1074/jbc.M907971199. PMID 10749879. 
  • Duque JL, Adam RM, Mullen JS, et al. (2001). "Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro.". J. Urol. 165 (1): 284–8. doi:10.1097/00005392-200101000-00080. PMID 11125426. 
  • Lin J, Hutchinson L, Gaston SM, et al. (2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation.". J. Biol. Chem. 276 (32): 30127–32. doi:10.1074/jbc.M010237200. PMID 11340068. 

[edit] External links

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