Heparan-alpha-glucosaminide N-acetyltransferase

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In enzymology, a heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + heparan sulfate alpha-D-glucosaminide $\rightleftharpoons$ CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide

Thus, the two substrates of this enzyme are acetyl-CoA and heparan sulfate alpha-D-glucosaminide, whereas its two products are CoA and heparan sulfate N-acetyl-alpha-D-glucosaminide.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase. This enzyme is also called acetyl-CoA:alpha-glucosaminide N-acetyltransferase. This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.

[edit] References

IUBMB entry for 2.3.1.78
BRENDA references for 2.3.1.78 (Recommended.)
PubMed references for 2.3.1.78
PubMed Central references for 2.3.1.78
Google Scholar references for 2.3.1.78
Klein U, Kresse H, von Figura K (1978). "Sanfilippo syndrome type C: deficiency of acetyl-CoA:alpha-glucosaminide N-acetyltransferase in skin fibroblasts". Proc. Natl. Acad. Sci. U. S. A. 75: 5185–9. doi:10.1073/pnas.75.10.5185. PMID 33384.
Pohlmann R, Klein U, Fromme HG, von Figura K (1981). "Localisation of acetyl-CoA: alpha-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver". Hoppe. Seylers. Z. Physiol. Chem. 362: 1199–207. PMID 7346380.