Talk:Hedgehog signaling pathway
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) This article seems pretty good, but I think needs a bit of de-jargoning to progress to GA standard Ciar 05:23, 14 April 2007 (UTC) |
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Excellent, I didnt realize someone had made a page about the molecule already (Sonic hedgehog) because there were no links to it. This page should be deleted; failure to realize page already existed attributed to lack of organization on Wikipedia, as links to the previously created page were absent. Note to future contributers: add links to your page on related pages!!!MrPMonday 07:49, 15 May 2006 (UTC)
[edit] Expansion
This page should be devoted to the hedgehog signaling pathway. Sonic hedgehog as a protein has its own page. This is they way I think it would be best to structure the article:
- Intro
- Discovery
- In Drosophila
- Function - role in development
- Mechanism - Hedgehog signaling in fruitflies
- In mammals
- Function - development, stem cells
- Mechanism (I can add some infromation about smo ptch regulations and also i think it might be time to add some info about cilia)
- Human disease - mutations in HH pathway lead to holoprosencephaly, disregulation to cancer, advances in drug design go here (I can comment on this in more detail and maybe create a few diagrams)
- Evolution - this is not crucial but would be nice, contrast fly and mammals here, mention zebrafish, hypotheses of when the pathway evolved (AFAIK it's not present in c. elegans, The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans), relationship to Wnt.
Peter Z.Talk 14:16, 22 June 2006 (UTC)
References A few papers I would like to incorporate into the article... This list will be extended.
- Rahnama F, Shimokawa T, Lauth M, Finta C, Kogerman P, Teglund S, Toftgard R and Zaphiropoulos PG (2006). "Inhibition of GLI1 gene activation by Patched1". Biochem J 394: 19-26. Entrez PubMed 16229683
- Jeong J and McMahon AP (2005). "Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1". Development 132 (1): 143-154. Entrez PubMed 15576403
- Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP and Tabin CJ (2004). "Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities" 118 (4): 517-528. Entrez PubMed 15315763
- Tian H, Jeong J, Harfe BD, Tabin CJ and McMahon AP (2005). "Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand". Development 132 (1): 133-142. Entrez PubMed 15576405
- This article - [1] and this table in particular [2]. There's a wealth of meterial there, any help sorting through for notable examples would be very welcome.
Peter Z.Talk 21:35, 23 June 2006 (UTC)
- SHH rapidly evolved during recent human evolution, perhaps contributing to the increase in brain size and complexity - Entrez PubMed 15620360 --Peter Z.Talk 20:51, 25 June 2006 (UTC)
John, just to let you know - I am adapting a figure on evolution of hedgehog ligands. Peter Z.Talk 18:45, 28 June 2006 (UTC)
- This article is indeed a fine example of how the articles should look. Fabuluous work. -- Boris 23:54, 29 June 2006 (UTC)
- The images themselves are great, but I see Image:HedgehogCiR.png crowding Image:Wingless.png to the right and compressing the text. But this is at 1920x1200, which isn't the most common resolution - has anyone else noticed a problem? Opabinia regalis 02:18, 30 June 2006 (UTC)
- I've made a slight change to the placement of images... It seems to work fine on 1400x1050 and lower. If you still have the same problem, would you mind emailing me a screenshot to oook dot pz at gmail dot com? --Peter Z.Talk 08:50, 30 June 2006 (UTC)
- I still see an overlap at this resolution - screenshot sent. Opabinia regalis 01:44, 1 July 2006 (UTC)
- I've made a slight change to the placement of images... It seems to work fine on 1400x1050 and lower. If you still have the same problem, would you mind emailing me a screenshot to oook dot pz at gmail dot com? --Peter Z.Talk 08:50, 30 June 2006 (UTC)
- The images themselves are great, but I see Image:HedgehogCiR.png crowding Image:Wingless.png to the right and compressing the text. But this is at 1920x1200, which isn't the most common resolution - has anyone else noticed a problem? Opabinia regalis 02:18, 30 June 2006 (UTC)
[edit] Is...?
Yeah. Um. Under "Fruit Fly" and the Sub-Heading "Roles," is the word "Frizzled" at the end of the first sentence of the third paragraph supposed to be there? Just wondering. --Heero Kirashami (talk) 20:05, 31 December 2007 (UTC)
