HDAC3

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Histone deacetylase 3
Identifiers
Symbol(s)	HDAC3; RPD3; HD3; RPD3-2
External IDs	OMIM: 605166 MGI: 1343091 HomoloGene: 48250
Gene ontology Molecular Function: • DNA binding • histone deacetylase activity • transcription factor binding • hydrolase activity Cellular Component: • histone deacetylase complex • nucleus • cytoplasm Biological Process: • transcription • regulation of transcription, DNA-dependent • anti-apoptosis • regulation of progression through mitotic cell cycle • chromatin modification • histone deacetylation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	8841	15183
Ensembl	ENSG00000171720	ENSMUSG00000024454
Uniprot	O15379	Q3UM33
Refseq	NM_003883 (mRNA) NP_003874 (protein)	NM_010411 (mRNA) NP_034541 (protein)
Location	Chr 5: 140.98 - 141 Mb	Chr 18: 38.06 - 38.08 Mb
Pubmed search	[1]	[2]

Histone deacetylase 3, also known as HDAC3, is a human gene.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.^[1]

Contents 1 See also 2 References 3 Further reading 4 External links

[edit] See also

• Histone deacetylase

[edit] References

[edit] Further reading

[edit] External links

• MeSH HDAC3+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.