HDAC11

From Wikipedia, the free encyclopedia

Histone deacetylase 11

Identifiers

HDAC11; FLJ22237

External IDs

OMIM: 607226 MGI: 2385252 HomoloGene: 11743

Gene ontology
Molecular Function:	• histone deacetylase activity • transcription factor binding • hydrolase activity
Cellular Component:	• histone deacetylase complex • nucleus • plasma membrane
Biological Process:	• transcription • regulation of transcription, DNA-dependent • chromatin modification • histone deacetylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024827 (mRNA)
NP_079103 (protein)

NM_144919 (mRNA)
NP_659168 (protein)

Location

Chr 3: 13.5 - 13.52 Mb

Chr 6: 91.12 - 91.14 Mb

Pubmed search

[1]

[2]

Histone deacetylase 11, also known as HDAC11, is a human gene.^[1]

Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.[supplied by OMIM]^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Histone deacetylase

[edit] References

^ ^a ^b Entrez Gene: HDAC11 histone deacetylase 11.

[edit] Further reading

Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators.". Trends Genet. 19 (5): 286-93. PMID 12711221.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Gao L, Cueto MA, Asselbergs F, Atadja P (2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.". J. Biol. Chem. 277 (28): 25748-55. doi:10.1074/jbc.M111871200. PMID 11948178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Voelter-Mahlknecht S, Ho AD, Mahlknecht U (2005). "Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene.". Int. J. Mol. Med. 16 (4): 589-98. PMID 16142391.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Lindberg D, Akerström G, Westin G (2007). "Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours.". Clin. Endocrinol. (Oxf) 66 (1): 110-4. doi:10.1111/j.1365-2265.2006.02694.x. PMID 17201809.