HBXIP

From Wikipedia, the free encyclopedia

Hepatitis B virus x interacting protein

Identifiers

HBXIP; MGC71071; XIP

External IDs

OMIM: 608521 MGI: 1915826 HomoloGene: 4668

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cytosol
Biological Process:	• anti-apoptosis • response to virus • viral genome replication • negative regulation of caspase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006402 (mRNA)
NP_006393 (protein)

XM_909856 (mRNA)
XP_914949 (protein)

Location

Chr 1: 110.75 - 110.75 Mb

Chr X: 154.93 - 154.93 Mb

Pubmed search

[1]

[2]

Hepatitis B virus x interacting protein, also known as HBXIP, is a human gene.^[1]

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.^[1]

[edit] References

^ ^a ^b Entrez Gene: HBXIP hepatitis B virus x interacting protein.

[edit] Further reading

Melegari M, Scaglioni PP, Wands JR (1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.". J. Virol. 72 (3): 1737–43. PMID 9499022.
Shamay M, Barak O, Doitsh G, et al. (2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription.". J. Biol. Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells.". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Marusawa H, Matsuzawa S, Welsh K, et al. (2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression.". EMBO J. 22 (11): 2729–40. doi:10.1093/emboj/cdg263. PMID 12773388.
Kong HJ, Park MJ, Hong S, et al. (2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2.". Hepatology 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lee SH, Park SG, Lim SO, Jung G (2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes.". Biochim. Biophys. Acta 1741 (1-2): 75–84. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.
Lee AT, Ren J, Wong ET, et al. (2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage.". J. Biol. Chem. 280 (39): 33525–35. doi:10.1074/jbc.M506628200. PMID 16055925.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Minczuk M, Mroczek S, Pawlak SD, Stepien PP (2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP.". FEBS J. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273.
Muroyama R, Kato N, Yoshida H, et al. (2007). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma.". J. Hepatol. 45 (6): 805–12. doi:10.1016/j.jhep.2006.07.025. PMID 17050029.
Chen J, Siddiqui A (2007). "Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress.". J. Virol. 81 (12): 6757–60. doi:10.1128/JVI.00172-07. PMID 17428866.