HBG2

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Hemoglobin, gamma G
PDB rendering based on 1fdh.
Available structures: 1fdh, 1i3d, 1i3e
Identifiers
Symbol(s) HBG2;
External IDs OMIM: 142250 HomoloGene: 88327
Orthologs
Human Mouse
Entrez 3048 n/a


Refseq NM_000184 (mRNA)
NP_000175 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

Hemoglobin, gamma G, also known as HBG2, is a human gene. The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.[1]

[edit] References

  1. ^ Entrez Gene: HBG2 hemoglobin, gamma G.

[edit] Further reading

  • Gelinas R, Yagi M, Endlich B, et al. (1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene.". Prog. Clin. Biol. Res. 191: 125–39. PMID 2413469. 
  • Higgs DR, Vickers MA, Wilkie AO, et al. (1989). "A review of the molecular genetics of the human alpha-globin gene cluster.". Blood 73 (5): 1081–104. PMID 2649166. 
  • Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. PMID 12488461. 
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