HARS2

From Wikipedia, the free encyclopedia

Histidyl-tRNA synthetase 2, mitochondrial (putative)

Identifiers

HARS2; HARSL; HARSR; HO3

External IDs

OMIM: 600783 MGI: 1918041 HomoloGene: 40819

Gene ontology
Molecular Function:	• nucleotide binding • histidine-tRNA ligase activity • ATP binding • ligase activity
Cellular Component:	• cytoplasm • mitochondrion
Biological Process:	• histidyl-tRNA aminoacylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012208 (mRNA)
NP_036340 (protein)

NM_080636 (mRNA)
NP_542367 (protein)

Location

Chr 5: 140.05 - 140.06 Mb

Chr 18: 36.91 - 36.92 Mb

Pubmed search

[1]

[2]

Histidyl-tRNA synthetase 2, mitochondrial (putative), also known as HARS2, is a human gene.^[1]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.^[1]

[edit] References

^ ^a ^b Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative).

[edit] Further reading

Freist W, Verhey JF, Rühlmann A, et al. (1999). "Histidyl-tRNA synthetase.". Biol. Chem. 380 (6): 623-46. PMID 10430027.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lama J, Trono D (1998). "Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3.". J. Virol. 72 (2): 1671-6. PMID 9445076.
Tsui HW, Mok S, de Souza L, et al. (1993). "Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element.". Gene 131 (2): 201-8. PMID 8406012.
O'Hanlon TP, Raben N, Miller FW (1995). "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS.". Biochem. Biophys. Res. Commun. 210 (2): 556-66. PMID 7755634.
Raben N, Borriello F, Amin J, et al. (1992). "Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases.". Nucleic Acids Res. 20 (5): 1075-81. PMID 1549469.