Talk:Haplotype

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This article is way too complicated to be understood by the general population

This is likely to be because the article as it stands is extremely poorly written and inaccurate. As a genetics statistician there are glaring inaccuracies. When I first came across it the base definition of a haplotype was that it may refer to one locus or a whole genome. This is just plainly wrong, and consulting any decent text book on genetics will demonstrate this (e.g. Bruce Weir's "Genetic Data Analysis II"; Pak Sham's "Statistics in Human Genetics"; Daniel Hartl's "Primer of Population Genetics"). I shall start working on re-writing this in a clear and succinct manner. Slack---line 14:31, 2 August 2007 (UTC)

Also I've noticed that in this and the article on linkage disequilibrium there are links to the proprietry software GoldenHelix. This may represent a conflict of interest. Besides there are plenty of free open-source software packages around that can calculate LD and haplotypes. Slack---line 14:31, 2 August 2007 (UTC)

I suggest the following ToDo list:

  • Clear definition of what a hapltoype is (Done).
  • Clear diagrams of how genotypes on chromosomes are related to haplotypes.
  • Clear example of how ambiguous phase leads to problems in determining an individuals haplotype from their genotype.
  • Discussion of [EM_algorithm] in estimating haplotype frequencies.
  • Discussion of Bayesian methods for estimating haplotype frequencies.
  • Haplotype associations in human genetics and disease mapping.
  • Detailed list of references on statistical aspects of resolving haplotypes.
  • Links to software used for estimating haplotypes (both EM and Bayesian).
  • Too much focus on the Y-chromosome. This is really a very small portion of the genome, and resolving haplotypes on the Y-chromosome is really quite easy, since males are homogametic and only carry one copy.

Slack---line 14:39, 2 August 2007 (UTC)

[edit] Microsatellites

Don't they use microsatellites more than SNPs nowadays to determine a patient's haplotype ? XApple 23:16, 17 October 2007 (UTC)