HAPLN1

From Wikipedia, the free encyclopedia


Hyaluronan and proteoglycan link protein 1
Identifiers
Symbol(s) HAPLN1; CRTL1
External IDs OMIM: 115435 MGI: 1337006 HomoloGene: 1420
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1404 12950
Ensembl ENSG00000145681 ENSMUSG00000021613
Uniprot P10915 Q9QUP5
Refseq NM_001884 (mRNA)
NP_001875 (protein)		 NM_013500 (mRNA)
NP_038528 (protein)
Location Chr 5: 82.97 - 83.05 Mb Chr 13: 90.01 - 90.09 Mb
Pubmed search [1] [2]

Hyaluronan and proteoglycan link protein 1, also known as HAPLN1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: HAPLN1 hyaluronan and proteoglycan link protein 1.

[edit] Further reading

  • Mundlos S, Meyer R, Yamada Y, Zabel B (1992). "Distribution of cartilage proteoglycan (aggrecan) core protein and link protein gene expression during human skeletal development.". Matrix 11 (5): 339–46. PMID 1725805. 
  • Rhodes C, Savagner P, Line S, et al. (1991). "Characterization of the promoter for the rat and human link protein gene.". Nucleic Acids Res. 19 (8): 1933–9. PMID 2030970. 
  • Osborne-Lawrence SL, Sinclair AK, Hicks RC, et al. (1991). "Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene.". Genomics 8 (3): 562–7. PMID 2286376. 
  • Dudhia J, Hardingham TE (1990). "The primary structure of human cartilage link protein.". Nucleic Acids Res. 18 (5): 1292. PMID 2320422. 
  • Dudhia J, Hardingham TE (1990). "The primary structure of human cartilage link protein.". Nucleic Acids Res. 18 (8): 2214. PMID 2336413. 
  • Perkins SJ, Nealis AS, Dudhia J, Hardingham TE (1989). "Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein.". J. Mol. Biol. 206 (4): 737–53. PMID 2738916. 
  • Nguyen Q, Murphy G, Hughes CE, et al. (1993). "Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein.". Biochem. J. 295 ( Pt 2): 595–8. PMID 7694569. 
  • Dudhia J, Bayliss MT, Hardingham TE (1994). "Human link protein gene: structure and transcription pattern in chondrocytes.". Biochem. J. 303 ( Pt 1): 329–33. PMID 7945259. 
  • Guerassimov A, Zhang Y, Banerjee S, et al. (1998). "Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis.". J. Rheumatol. 25 (8): 1480–4. PMID 9712087. 
  • Perveen R, Hart-Holden N, Dixon MJ, et al. (1999). "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3.". Genomics 57 (2): 219–26. doi:10.1006/geno.1999.5766. PMID 10198161. 
  • Hirakawa S, Oohashi T, Su WD, et al. (2000). "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.". Biochem. Biophys. Res. Commun. 276 (3): 982–9. doi:10.1006/bbrc.2000.3583. PMID 11027579. 
  • Pokharna HK, Pottenger LA (2000). "Glycation induced crosslinking of link proteins, in vivo and in vitro.". J. Surg. Res. 94 (1): 35–42. doi:10.1006/jsre.2000.6000. PMID 11038300. 
  • Milz S, Schlüter T, Putz R, et al. (2001). "Fibrocartilage in the transverse ligament of the human atlas.". Spine 26 (16): 1765–71. PMID 11493848. 
  • Sun GW, Kobayashi H, Suzuki M, et al. (2003). "Production of cartilage link protein by human granulosa-lutein cells.". J. Endocrinol. 175 (2): 505–15. PMID 12429048. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Spicer AP, Joo A, Bowling RA (2003). "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.". J. Biol. Chem. 278 (23): 21083–91. doi:10.1074/jbc.M213100200. PMID 12663660. 
  • Matsumoto K, Shionyu M, Go M, et al. (2003). "Distinct interaction of versican/PG-M with hyaluronan and link protein.". J. Biol. Chem. 278 (42): 41205–12. doi:10.1074/jbc.M305060200. PMID 12888576. 
  • Shi S, Grothe S, Zhang Y, et al. (2004). "Link protein has greater affinity for versican than aggrecan.". J. Biol. Chem. 279 (13): 12060–6. doi:10.1074/jbc.M310091200. PMID 14724283. 
  • Kou I, Ikegawa S (2005). "SOX9-dependent and -independent transcriptional regulation of human cartilage link protein.". J. Biol. Chem. 279 (49): 50942–8. doi:10.1074/jbc.M406786200. PMID 15456769. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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