Haloalkane dehalogenase

From Wikipedia, the free encyclopedia

In enzymology, a haloalkane dehalogenase (EC 3.8.1.5) is an enzyme that catalyzes the chemical reaction

1-haloalkane + H₂O $\rightleftharpoons$ a primary alcohol + halide

Thus, the two substrates of this enzyme are 1-haloalkane and H₂O, whereas its two products are primary alcohol and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 1-haloalkane halidohydrolase. Other names in common use include 1-chlorohexane halidohydrolase, and 1-haloalkane dehalogenase. This enzyme participates in 4 metabolic pathways: gamma-hexachlorocyclohexane degradation, naphthalene and anthracene degradation, 1,2-dichloroethane degradation, and 3-chloroacrylic acid degradation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes 1B6G, 1BE0, 1BEE, 1BEZ, 1BN6, 1BN7, 1CIJ, 1CQW, 1CV2, 1D07, 1EDB, 1EDD, 1EDE, 1HDE, 1K5P, 1K63, 1K6E, 1MJ5, 2DHC, 2DHD, 2DHE, 2EDA, 2EDC, 2PKY, and 2YXP.

[edit] References

IUBMB entry for 3.8.1.5
BRENDA references for 3.8.1.5 (Recommended.)
PubMed references for 3.8.1.5
PubMed Central references for 3.8.1.5
Google Scholar references for 3.8.1.5
Keuning S, Janssen DB, Witholt B (1985). "Purification and characterization of hydrolytic haloalkane dehalogenase from Xanthobacter autotrophicus GJ10". J. Bacteriol. 163: 635–9. PMID 4019411.
Scholtz R, Leisinger T, Suter F, Cook AM (1987). "Characterization of 1-chlorohexane halidohydrolase, a dehalogenase of wide substrate range from an Arthrobacter sp". J. Bacteriol. 169: 5016–21. PMID 3667524.
Yokota T, Omori T, Kodama T (1987). "Purification and properties of haloalkane dehalogenase from Corynebacterium sp. strain m15-3". J. Bacteriol. 169: 4049–54. PMID 3624201.