H2AFY

From Wikipedia, the free encyclopedia

H2A histone family, member Y

PDB rendering based on 1u35.

Available structures: 1u35, 1yd9, 1zr3, 1zr5, 2f8n, 2fxk

Identifiers

Symbol(s)

H2AFY; H2A.y; H2A/y; H2AF12M; H2AFJ; MACROH2A1.1; mH2A1; macroH2A1.2

External IDs

OMIM: 610054 MGI: 1349392 HomoloGene: 3598

Gene ontology
Molecular Function:	• DNA binding • chromatin binding
Cellular Component:	• nucleosome • condensed chromosome • Barr body • nucleus
Biological Process:	• nucleosome assembly • chromosome organization and biogenesis (sensu Eukaryota) • dosage compensation • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040158 (mRNA)
NP_001035248 (protein)

XM_923889 (mRNA)
XP_928982 (protein)

Location

Chr 5: 134.7 - 134.76 Mb

Chr 13: 56.08 - 56.15 Mb

Pubmed search

[1]

[2]

H2A histone family, member Y, also known as H2AFY, is a human gene.^[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: H2AFY H2A histone family, member Y.

[edit] Further reading

El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535–44. PMID 9566873.
Costanzi C, Pehrson JR (1998). "Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals.". Nature 393 (6685): 599–601. doi:10.1038/31275. PMID 9634239.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. PMID 9653160.
Lee Y, Hong M, Kim JW, et al. (1998). "Isolation of cDNA clones encoding human histone macroH2A1 subtypes.". Biochim. Biophys. Acta 1399 (1): 73–7. PMID 9714746.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Chadwick BP, Willard HF (2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant.". Hum. Mol. Genet. 10 (10): 1101–13. PMID 11331621.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Chadwick BP, Willard HF (2002). "Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome.". J. Cell Biol. 157 (7): 1113–23. doi:10.1083/jcb.200112074. PMID 12082075.
Takahashi I, Kameoka Y, Hashimoto K (2002). "MacroH2A1.2 binds the nuclear protein Spop.". Biochim. Biophys. Acta 1591 (1-3): 63–8. PMID 12183056.
Ganesan S, Silver DP, Greenberg RA, et al. (2002). "BRCA1 supports XIST RNA concentration on the inactive X chromosome.". Cell 111 (3): 393–405. PMID 12419249.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Angelov D, Molla A, Perche PY, et al. (2003). "The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling.". Mol. Cell 11 (4): 1033–41. PMID 12718888.
Behrends U, Schneider I, Rössler S, et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.". Int. J. Cancer 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMID 14657027.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, et al. (2004). "Respiratory complex III is required to maintain complex I in mammalian mitochondria.". Mol. Cell 13 (6): 805–15. PMID 15053874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang R, Poustovoitov MV, Ye X, et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.". Dev. Cell 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.
Hernández-Muñoz I, Lund AH, van der Stoop P, et al. (2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7635–40. doi:10.1073/pnas.0408918102. PMID 15897469.