GZMH

From Wikipedia, the free encyclopedia

Granzyme H (cathepsin G-like 2, protein h-CCPX)

Identifiers

GZMH; CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2

External IDs

OMIM: 116831 MGI: 109253 HomoloGene: 62159

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • peptidase activity
Cellular Component:	• cytoplasm
Biological Process:	• proteolysis • apoptosis • cytolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_033423 (mRNA)
NP_219491 (protein)

NM_010375 (mRNA)
NP_034505 (protein)

Location

Chr 14: 24.15 - 24.15 Mb

Chr 14: 55.11 - 55.11 Mb

Pubmed search

[1]

[2]

Granzyme H (cathepsin G-like 2, protein h-CCPX), also known as GZMH, is a human gene.^[1]

[edit] References

^ Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX).

[edit] Further reading

Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells.". Trends Immunol. 28 (9): 373–5. doi:10.1016/j.it.2007.08.001. PMID 17766182.
Llorens C, Martres MP, Baudry M, Schwartz JC (1978). "Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence.". Nature 274 (5671): 603–5. PMID 209336.
Heusel JW, Hanson RD, Silverman GA, Ley TJ (1991). "Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.". J. Biol. Chem. 266 (10): 6152–8. PMID 2007574.
Haddad P, Jenne D, Tschopp J, et al. (1991). "Structure and evolutionary origin of the human granzyme H gene.". Int. Immunol. 3 (1): 57–66. PMID 2049336.
Meier M, Kwong PC, Frégeau CJ, et al. (1990). "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family.". Biochemistry 29 (17): 4042–9. PMID 2193684.
Hanson RD, Hohn PA, Popescu NC, Ley TJ (1990). "A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 960–3. PMID 2300587.
Klein JL, Selvakumar A, Trapani JA, Dupont B (1990). "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C).". Tissue Antigens 35 (5): 220–8. PMID 2402757.
MacIvor DM, Pham CT, Ley TJ (1999). "The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice.". Blood 93 (3): 963–73. PMID 9920846.
Edwards KM, Kam CM, Powers JC, Trapani JA (1999). "The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes.". J. Biol. Chem. 274 (43): 30468–73. PMID 10521426.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ (2003). "Cell death induced by granzyme C.". Blood 101 (8): 3093–101. doi:10.1182/blood-2002-08-2485. PMID 12515723.
Sedelies KA, Sayers TJ, Edwards KM, et al. (2004). "Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.". J. Biol. Chem. 279 (25): 26581–7. doi:10.1074/jbc.M312481200. PMID 15069086.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andrade F, Fellows E, Jenne DE, et al. (2007). "Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition.". EMBO J. 26 (8): 2148–57. doi:10.1038/sj.emboj.7601650. PMID 17363894.
Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). "Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program.". Blood 110 (2): 544–52. doi:10.1182/blood-2006-10-051649. PMID 17409270.