GUCY1A3

From Wikipedia, the free encyclopedia

Guanylate cyclase 1, soluble, alpha 3

Identifiers

GUCY1A3; GC-SA3; GUC1A3; GUCA3; GUCSA3

External IDs

OMIM: 139396 MGI: 1926562 HomoloGene: 37360

Gene ontology
Molecular Function:	• guanylate cyclase activity • receptor activity
Cellular Component:	• guanylate cyclase complex, soluble
Biological Process:	• cGMP biosynthetic process • nitric oxide mediated signal transduction • circulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000856 (mRNA)
NP_000847 (protein)

NM_021896 (mRNA)
NP_068696 (protein)

Location

Chr 4: 156.81 - 156.87 Mb

Chr 3: 82.18 - 82.23 Mb

Pubmed search

[1]

[2]

Guanylate cyclase 1, soluble, alpha 3, also known as GUCY1A3, is a human gene.^[1]

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3.

[edit] Further reading

Giuili G, Scholl U, Bulle F, Guellaën G (1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.". FEBS Lett. 304 (1): 83-8. PMID 1352257.
Giuili G, Roechel N, Scholl U, et al. (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.". Hum. Genet. 91 (3): 257-60. PMID 8097486.
Papapetropoulos A, Cziraki A, Rubin JW, et al. (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.". J. Cell. Physiol. 167 (2): 213-21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family.". Biochem. J. 335 ( Pt 1): 51-7. PMID 9742212.
Zhou Y, Zheng JB, Gu X, et al. (2000). "A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?". Gene 245 (2): 319-28. PMID 10717483.
Behrends S, Vehse K, Scholz H, et al. (2000). "Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1-->q31.2 by in situ hybridization.". Cytogenet. Cell Genet. 88 (3-4): 204-5. PMID 10828587.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Saino M, Maruyama T, Sekiya T, et al. (2005). "Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3.". Oncol. Rep. 12 (1): 47-52. PMID 15201957.
Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.". J. Biol. Chem. 279 (47): 49346-54. doi:10.1074/jbc.M410565200. PMID 15381706.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.