Guanosine-triphosphate guanylyltransferase

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In enzymology, a guanosine-triphosphate guanylyltransferase (EC 2.7.7.45) is an enzyme that catalyzes the chemical reaction

2 GTP diphosphate + P₁,P₄-bis(5'-guanosyl) tetraphosphate

Hence, this enzyme has one substrate, GTP, and two products, diphosphate and P1,P4-bis(5'-guanosyl) tetraphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:GTP guanylyltransferase. Other names in common use include diguanosine tetraphosphate synthetase, GTP-GTP guanylyltransferase, Gp4G synthetase, and guanosine triphosphate-guanose triphosphate guanylyltransferase.

[edit] References

• IUBMB entry for 2.7.7.45
• BRENDA references for 2.7.7.45 (Recommended.)
• PubMed references for 2.7.7.45
• PubMed Central references for 2.7.7.45
• Google Scholar references for 2.7.7.45
• Warner AH, Beers PC, Huang FL (1974). "Biosynthesis of the diguanosine nucleotides. I. Purification and properties of an enzyme from yolk platelets of brine shrimp embryos". Can. J. Biochem. 52: 231–40. PMID 4208243. 

[edit] External links

The CAS registry number for this enzyme class is 54576-89-5.

• IUBMB entry for 2.7.7.45

• KEGG entry for 2.7.7.45

• BRENDA entry for 2.7.7.45

• NiceZyme view of 2.7.7.45

• EC2PDB: PDB structures for 2.7.7.45

• PRIAM entry for 2.7.7.45

• PUMA2 entry for 2.7.7.45

• IntEnz: Integrated Enzyme entry for 2.7.7.45

• MetaCyc entry for 2.7.7.45

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047351: guanosine-triphosphate guanylyltransferase

• AMIGO entry for GO code 0047351: guanosine-triphosphate guanylyltransferase