GSTO1

From Wikipedia, the free encyclopedia

Glutathione S-transferase omega 1

PDB rendering based on 1eem.

Available structures: 1eem

Identifiers

Symbol(s)

GSTO1; P28; DKFZp686H13163; GSTTLp28

External IDs

OMIM: 605482 MGI: 1342273 HomoloGene: 37971

Gene ontology
Molecular Function:	• glutathione transferase activity • monodehydroascorbate reductase (NADH) activity • transferase activity
Cellular Component:	• cytoplasm
Biological Process:	• metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004832 (mRNA)
NP_004823 (protein)

NM_010362 (mRNA)
NP_034492 (protein)

Location

Chr 10: 106 - 106.02 Mb

Chr 19: 47.91 - 47.92 Mb

Pubmed search

[1]

[2]

Glutathione S-transferase omega 1, also known as GSTO1, is a human gene.^[1]

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.^[1]

[edit] References

^ ^a ^b Entrez Gene: GSTO1 glutathione S-transferase omega 1.

[edit] Further reading

Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. PMID 8076819.
Ishikawa T, Casini AF, Nishikimi M (1998). "Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase.". J. Biol. Chem. 273 (44): 28708–12. PMID 9786866.
Kodym R, Calkins P, Story M (1999). "The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins.". J. Biol. Chem. 274 (8): 5131–7. PMID 9988762.
Board PG, Coggan M, Chelvanayagam G, et al. (2000). "Identification, characterization, and crystal structure of the Omega class glutathione transferases.". J. Biol. Chem. 275 (32): 24798–806. doi:10.1074/jbc.M001706200. PMID 10783391.
Hubbard MJ, McHugh NJ (2001). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.". Electrophoresis 21 (17): 3785–96. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497.
Yin ZL, Dahlstrom JE, Le Couteur DG, Board PG (2001). "Immunohistochemistry of omega class glutathione S-transferase in human tissues.". J. Histochem. Cytochem. 49 (8): 983–7. PMID 11457926.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tanaka-Kagawa T, Jinno H, Hasegawa T, et al. (2003). "Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn).". Biochem. Biophys. Res. Commun. 301 (2): 516–20. PMID 12565892.
Whitbread AK, Tetlow N, Eyre HJ, et al. (2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms.". Pharmacogenetics 13 (3): 131–44. doi:10.1097/01.fpc.0000054062.98065.6e. PMID 12618591.
Yu L, Kalla K, Guthrie E, et al. (2004). "Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans.". Environ. Health Perspect. 111 (11): 1421–7. PMID 12928150.
Li YJ, Oliveira SA, Xu P, et al. (2004). "Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.". Hum. Mol. Genet. 12 (24): 3259–67. doi:10.1093/hmg/ddg357. PMID 14570706.
Whitbread AK, Mellick GD, Silburn PA, et al. (2004). "Glutathione transferase Omega class polymorphisms in Parkinson disease.". Neurology 62 (10): 1910–1. PMID 15159516.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kölsch H, Linnebank M, Lütjohann D, et al. (2005). "Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.". Neurology 63 (12): 2255–60. PMID 15623683.
Ozturk A, Desai PP, Minster RL, et al. (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease.". Neurobiol. Aging 26 (8): 1161–5. doi:10.1016/j.neurobiolaging.2004.11.001. PMID 15917099.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Fujihara J, Kunito T, Takeshita H (2007). "Frequency of two human glutathione-S-transferase omega-1 polymorphisms (E155 deletion and E208K) in Ovambo and Japanese populations using the PCR-based genotyping method.". Clin. Chem. Lab. Med. 45 (5): 621–4. doi:10.1515/CCLM.2007.128. PMID 17484623.
Harju TH, Peltoniemi MJ, Rytilä PH, et al. (2007). "Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients.". Respir. Res. 8: 48. doi:10.1186/1465-9921-8-48. PMID 17617905.
Kölsch H, Larionov S, Dedeck O, et al. (2007). "Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression.". Stroke 38 (10): 2847–50. doi:10.1161/STROKEAHA.107.484162. PMID 17717316.