Growth hormone 1

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Growth hormone 1
PDB rendering based on 1a22.
Available structures: 1a22, 1axi, 1bp3, 1hgu, 1huw, 1hwg, 1hwh, 1kf9, 3hhr
Identifiers
Symbol(s)	GH1; GH; GH-N; GHN; hGH-N
External IDs	OMIM: 139250
Gene ontology Molecular Function: • hormone activity • protein binding Cellular Component: • extracellular region Biological Process: • signal transduction
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2688	n/a
Ensembl	ENSG00000189162	n/a
Uniprot	P01241	n/a
Refseq	NM_000515 (mRNA) NP_000506 (protein)	n/a (mRNA) n/a (protein)
Location	Chr 17: 59.35 - 59.35 Mb	n/a
Pubmed search	[1]	n/a

Growth hormone 1, also known as GH1, is a human gene.

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.^[1]

[edit] See also

• Growth hormone

[edit] References

[edit] Further reading