GRK5

From Wikipedia, the free encyclopedia

G protein-coupled receptor kinase 5

Identifiers

GRK5; GPRK5

External IDs

OMIM: 600870 MGI: 109161 HomoloGene: 3879

Gene ontology
Molecular Function:	• nucleotide binding • G-protein coupled receptor kinase activity • signal transducer activity • protein kinase C binding • ATP binding • phospholipid binding • transferase activity
Cellular Component:	• soluble fraction • cytoplasm
Biological Process:	• protein amino acid phosphorylation • signal transduction • G-protein signaling, coupled to cAMP nucleotide second messenger • regulation of G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005308 (mRNA)
NP_005299 (protein)

XM_977246 (mRNA)
XP_982340 (protein)

Location

Chr 10: 120.96 - 121.21 Mb

Chr 19: 60.95 - 61.15 Mb

Pubmed search

[1]

[2]

G protein-coupled receptor kinase 5, also known as GRK5, is a human gene.^[1]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).^[1]

[edit] References

^ ^a ^b Entrez Gene: GRK5 G protein-coupled receptor kinase 5.

[edit] Further reading

Kunapuli P, Benovic JL (1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5588–92. PMID 7685906.
Bullrich F, Druck T, Kunapuli P, et al. (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.". Cytogenet. Cell Genet. 70 (3-4): 250–4. PMID 7789183.
Kunapuli P, Gurevich VV, Benovic JL (1994). "Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.". J. Biol. Chem. 269 (14): 10209–12. PMID 8144599.
Kunapuli P, Onorato JJ, Hosey MM, Benovic JL (1994). "Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.". J. Biol. Chem. 269 (2): 1099–105. PMID 8288567.
Nagayama Y, Tanaka K, Hara T, et al. (1996). "Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor.". J. Biol. Chem. 271 (17): 10143–8. PMID 8626574.
Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (1996). "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.". J. Biol. Chem. 271 (22): 13266–72. PMID 8662816.
Fredericks ZL, Pitcher JA, Lefkowitz RJ (1996). "Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor.". J. Biol. Chem. 271 (23): 13796–803. PMID 8662852.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Pronin AN, Carman CV, Benovic JL (1998). "Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation.". J. Biol. Chem. 273 (47): 31510–8. PMID 9813065.
Premont RT, Claing A, Vitale N, et al. (1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14082–7. PMID 9826657.
Carman CV, Lisanti MP, Benovic JL (1999). "Regulation of G protein-coupled receptor kinases by caveolin.". J. Biol. Chem. 274 (13): 8858–64. PMID 10085129.
Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (1999). "Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium.". J. Endocrinol. 162 (3): 401–8. PMID 10467231.
Okochi M, Walter J, Koyama A, et al. (2000). "Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.". J. Biol. Chem. 275 (1): 390–7. PMID 10617630.
Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000). "Synucleins are a novel class of substrates for G protein-coupled receptor kinases.". J. Biol. Chem. 275 (34): 26515–22. doi:10.1074/jbc.M003542200. PMID 10852916.
Berrada K, Plesnicher CL, Luo X, Thibonnier M (2000). "Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation.". J. Biol. Chem. 275 (35): 27229–37. doi:10.1074/jbc.M002288200. PMID 10858434.
Zhou H, Yan F, Tai HH (2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases.". J. Pharmacol. Exp. Ther. 298 (3): 1243–51. PMID 11504827.
Blaukat A, Pizard A, Breit A, et al. (2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.". J. Biol. Chem. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.
Hu LA, Chen W, Premont RT, et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.". J. Biol. Chem. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.
Warabi K, Richardson MD, Barry WT, et al. (2002). "Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro.". FEBS Lett. 521 (1-3): 140–4. PMID 12067742.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.