GPSM1

From Wikipedia, the free encyclopedia

G-protein signalling modulator 1 (AGS3-like, C. elegans)

Identifiers

GPSM1; AGS3; DKFZP727I051

External IDs

OMIM: 609491 MGI: 1915089 HomoloGene: 16987

Gene ontology
Molecular Function:	• GTPase activator activity • binding
Cellular Component:	• endoplasmic reticulum • membrane
Biological Process:	• signal transduction • multicellular organismal development • nervous system development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_939186 (mRNA)
XP_944279 (protein)

NM_153410 (mRNA)
NP_700459 (protein)

Location

n/a

Chr 2: 26.14 - 26.17 Mb

Pubmed search

[1]

[2]

G-protein signalling modulator 1 (AGS3-like, C. elegans), also known as GPSM1, is a human gene.^[1]

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans).

[edit] Further reading

Peterson YK, Bernard ML, Ma H, et al. (2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3.". J. Biol. Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID 10969064.
Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin.". J. Biol. Chem. 275 (52): 40981–5. doi:10.1074/jbc.M006478200. PMID 11024022.
Pizzinat N, Takesono A, Lanier SM (2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains.". J. Biol. Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID 11278352.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells.". J. Biol. Chem. 278 (23): 20995–1002. doi:10.1074/jbc.M300917200. PMID 12642577.
Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression.". Mol. Biol. Cell 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMID 12925752.
Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1.". J. Biol. Chem. 278 (51): 51825–32. doi:10.1074/jbc.M306300200. PMID 14530282.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins.". Cell 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.